Protocol for a Systematic Review and Meta-Analysis of Observational Studies on the Association of Exposure to Toxic Environmental Pollutants and Left Ventricular Dysfunction

Linzalone, Nunzia; Donzelli, Gabriele; Morales, Maria Aurora; Vozzi, Federico

doi:10.3390/ijerph19127482

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…Eventually, results from this systematic mapping review and meta-analyses will be integrated with a review on epidemiological evidence of PICT being performed in parallel (Linzalone et al, 2022). By doing so, outcomes seen at the population level (heart failure) can be linked to MIEs that start the cardiotoxicity cascade upon exposure, for example, by using the AOP framework.…”

Section: Chemical Namementioning

confidence: 99%

Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review

2023

ALTEX

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the leading cause of death globally, and the incidence of CVD is expected to rise with the aging population as age poses the largest risk factor for CVD (WHO, 2019;North and Sinclair, 2012). Additionally, exposure to environmental chemicals could be an important risk factor contributing to the development and severity of CVD (Cosselman et al., 2015). Indeed, several epidemiological studies and systematic reviews have linked the exposure to pollut- IntroductionHumans are continuously exposed to a vast amount and variety of potentially harmful substances that are ubiquitously present in the surrounding environment. Exposure to these environmental chemicals and their mixtures represents a source of concern due to their multi-organ damaging potential. Cardiovascular disease (CVD) is

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Section: Chemical Namementioning

confidence: 99%

Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review

2023

ALTEX

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A systematic review and meta-analysis of human population studies on the association between exposure to toxic environmental chemicals and left ventricular dysfunction (LVD)

Donzelli,

Sera,

Morales

et al. 2024

Environmental Research

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A critical review on the toxicological and epidemiological evidence integration for assessing human health risks to environmental chemical exposures

Donzelli,

Gehring,

Murugadoss

et al. 2024

Reviews on Environmental Health

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Toxicology and epidemiology are the two traditional public health scientific disciplines which can contribute to investigate harmful health effects of exposure to toxic substances. Several frameworks for integrating different lines of evidence were proposed since 2011, evolving based of the emergence of new methodologies and approaches. Through the comparison of various theoretical frameworks for evidence integration, we examined similarities, differences, strengths, and weaknesses to provide insights into potential directions for future research. We identified several key challenges of the integration approach to be applied to risk assessment. More specifically, collaboration within a multidisciplinary team of scientists, toxicologists, epidemiologists, and risk assessors, is strongly recommended to be aligned with key regulatory objectives and promote a harmonized approach. Moreover, literature search transparency and systematicity have to be ensured by following validated guidelines, developing parallel protocols for collecting epidemiological and toxicological evidence from various sources, including human, animal, and new approach methodologies (NAMs). Also, the adoption of tailored quality assessment tools is essential to grade the certainty in evidence. Lastly, we recommend the use of the Adverse Outcome Pathway framework to provide a structured understanding of toxicity mechanisms and allow the integration of human, animal, and NAMs data within a single framework.

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Protocol for a Systematic Review and Meta-Analysis of Observational Studies on the Association of Exposure to Toxic Environmental Pollutants and Left Ventricular Dysfunction

Cited by 3 publications

References 20 publications

Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review

Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review

A systematic review and meta-analysis of human population studies on the association between exposure to toxic environmental chemicals and left ventricular dysfunction (LVD)

A critical review on the toxicological and epidemiological evidence integration for assessing human health risks to environmental chemical exposures

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