Protocol for the development of a Core Outcome Set for trials on the prevention and treatment of Orthodontically induced enamel White Spot Lesions (COS-OWSL)

Qin, Danchen; Wang, Yunlei; Levey, Colin; Ngan, Peter; He, Hong; Hua, Fang

doi:10.1186/s13063-021-05371-w

Cited by 8 publications

(4 citation statements)

References 52 publications

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“…Thus, they did not form the halo of inhibition, making the 5% Agnano concentration the dose-response. Arch Health Invest (2023)12 (7)…”

Section: Resultsmentioning

confidence: 99%

“…WSL formation in the enamel around brackets is a serious and very common complication during orthodontic treatment 5 , with its prevalence being 73% to 95% 6 . Through this phenomenon, aesthetics can be compromised after the removal of the fixed orthodontic appliance and be a cause of post-treatment dissatisfaction 7 . Within this context, continuous efforts have been made to control white spot lesions by destructuring the biofilm, preventing enamel demineralization or promoting its remineralization 8 .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of an Experimental Gel Containing Biologically Synthesized Silver Nanoparticles used in the Biofilm Disruption

Antunes,

Rocha,

Marcelino

et al. 2023

Arch Health Invest

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The aim of the present study was to synthesize and evaluate the biological and mechanical properties of a polymeric gel associated with silver nanoparticles. The gels were composed of a Chitosan-Xanthan (CX) polyelectrolytic biopolymer complex associated or not with silver nanoparticles (Agnano), which were grouped into the following groups: G1) Gel CX; G2) CX Gel + 5% Agnano; G3) CX Gel + 2.5% Agnano; 4) CX Gel + 1.25% Agnano. The characterization of nanoparticles was performed through dynamic light scattering analysis, and gels through rheological analysis. The antimicrobial activity for Streptococcus mutans was performed by the inhibition halo method. The results obtained from DLS showed a Zeta potential of -30 mV and particle size approximately 100 nm. The rheological analysis shows that all groups had viscosity between 5 and 6.5 Pa, and with increasing shear stress the viscosity of all groups was decreased. For the analysis of antimicrobial activity, the antimicrobial potential was observed only for the CX gel containing 5% Agnano. Thus, it is concluded that the gel containing 5% Agnano is promising for use in orthodontic patients with a high rate of bacterial plaque and can be used to prevent white spot lesions during and after treatment.

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“…Thus, they did not form the halo of inhibition, making the 5% Agnano concentration the dose-response. Arch Health Invest (2023)12 (7)…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of an Experimental Gel Containing Biologically Synthesized Silver Nanoparticles used in the Biofilm Disruption

Antunes,

Rocha,

Marcelino

et al. 2023

Arch Health Invest

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show abstract

“…Moreover, none of our selected studies reflected the patient’s perspectives on the intervention and its adverse effects. Therefore, the development of a core outcome set for trials on the prevention and treatment of orthodontically induced enamel WSL ( 24 ) will certainly facilitate and enhance future studies in this area. It is however not enough to harmonize just what, when and how to measure; also the patients perspective should also be taken into account.…”

Section: Discussionmentioning

confidence: 99%

Prevention of white spot lesions with fluoride varnish during orthodontic treatment with fixed appliances: a systematic review

Sonesson

Twetman

2023

European Journal of Orthodontics

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Summary Background Fluoride varnish (FV) is an established technology for primary and secondary caries prevention. Objective The aim of this review was to evaluate the preventive effect of FV on development of white spot lesions (WSL) when regularly applied during orthodontic treatment with fixed appliances. Search methods We searched PubMed, Scopus and Google Scholar up to October 2022 using predetermined keywords. Selection criteria We included randomized controlled trials of a duration of minimum 12 months and at least quarterly FV applications. Data collection and analysis Based on abstracts, we retrieved full-text papers, extracted key outcome data, and assessed risk of bias. Primary outcome was prevalence of WSLs on subject level after debonding. We conducted a narrative synthesis and pooled comparable outcome data in a random effects model. Results We included seven studies covering 666 patients and assessed four publications with low or moderate risk of bias and three with high. The prevalence of WSLs at debonding varied between 12 and 55%. All studies presented results in favour for the FV intervention, one reached statistical significance on subject level. Five studies provided data for a meta-analysis. The pooled risk ratio was 0.64 [95% CI: 0.42, 0.98], indicating a statistically significant preventive effect. Certainty of evidence was graded as very low after reducing for risk of bias, inconsistency and imprecision. Limitations We pooled data on subject level and did not consider lesion severity on tooth level. Conclusions and implications Even if the certainty of evidence was very low, it was shown that FV can prevent development of WSL when regularly applied during orthodontic treatment. Larger investigations reporting a core outcome set are required to increase the certainty of evidence. Registration PROSPERO database (CRD42022370062).

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“…Further RCTs with proper design, long-term follow-up and well-selected outcome measures are still needed in this field. 10,11…”

Section: Commentary and Analysismentioning

confidence: 99%

Resin Infiltration May Be a Feasible Option to Esthetically Mask Enamel White Spot Lesions

Liu¹,

Huang²,

Hua³

2022

Journal of Evidence-Based Dental Practice

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Protocol for the development of a Core Outcome Set for trials on the prevention and treatment of Orthodontically induced enamel White Spot Lesions (COS-OWSL)

Cited by 8 publications

References 52 publications

Synthesis of an Experimental Gel Containing Biologically Synthesized Silver Nanoparticles used in the Biofilm Disruption

Synthesis of an Experimental Gel Containing Biologically Synthesized Silver Nanoparticles used in the Biofilm Disruption

Prevention of white spot lesions with fluoride varnish during orthodontic treatment with fixed appliances: a systematic review

Resin Infiltration May Be a Feasible Option to Esthetically Mask Enamel White Spot Lesions

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