2020
DOI: 10.1136/bmjopen-2020-041125
|View full text |Cite
|
Sign up to set email alerts
|

Protocol of a randomised controlled trial on the efficacy of medication optimisation in elderly inpatients: medication optimisation protocol efficacy for geriatric inpatients (MPEG) trial

Abstract: IntroductionWhether medication optimisation improves clinical outcomes in elderly individuals remains unclear. The current study aims to evaluate the effect of multidisciplinary team-based medication optimisation on survival, rehospitalisation and unscheduled hospital visits in elderly patients.Methods and analysisWe report the protocol of a single-centre, open-label, randomised controlled trial. The enrolled subjects will be medical inpatients, aged 65 years or older, admitted to a community hospital and rece… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
4
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

citations
Cited by 7 publications
(4 citation statements)
references
References 22 publications
0
4
0
Order By: Relevance
“…Building an Evidence Base for Deprescribing in the Setting of Polypharmacy Michelle C. Odden, PhD In this issue of JAMA Network Open, Ie and colleagues 1 evaluated the effect of a multidisciplinary team-based medication optimization program in older adult inpatients receiving 5 or more medications. 1 Between 2019 and 2022, 442 participants were recruited from 8 internal medicine wards in a single hospital in Japan. The participants were medically complex; they were selected based on an expected length of hospital stay of at least 1 week, and they had an average of 4 diagnoses at baseline and approximately one-quarter died within 1 year.…”
Section: Invited Commentary | Pharmacy and Clinical Pharmacologymentioning
confidence: 99%
See 2 more Smart Citations
“…Building an Evidence Base for Deprescribing in the Setting of Polypharmacy Michelle C. Odden, PhD In this issue of JAMA Network Open, Ie and colleagues 1 evaluated the effect of a multidisciplinary team-based medication optimization program in older adult inpatients receiving 5 or more medications. 1 Between 2019 and 2022, 442 participants were recruited from 8 internal medicine wards in a single hospital in Japan. The participants were medically complex; they were selected based on an expected length of hospital stay of at least 1 week, and they had an average of 4 diagnoses at baseline and approximately one-quarter died within 1 year.…”
Section: Invited Commentary | Pharmacy and Clinical Pharmacologymentioning
confidence: 99%
“…In this issue of JAMA Network Open , Ie and colleagues evaluated the effect of a multidisciplinary team–based medication optimization program in older adult inpatients receiving 5 or more medications . Between 2019 and 2022, 442 participants were recruited from 8 internal medicine wards in a single hospital in Japan.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…The structure of the intervention included: (1) baseline data collection, including age, sex, previous medical history, comorbid conditions, smoking status, physical measurements on admission (height, weight and vital signs), estimated glomerular filtration rate (eGFR), serum sodium and potassium level, and regularly prescribed medications, conducted through medical record review; (2) preliminary medication optimization proposal using a clinical-decision support system; baseline data were entered into a computer-based clinical-decision support system developed specifically for this trial by the deprescribing team using a Microsoft Excel spreadsheet. Using these data, the clinicaldecision support system generated a preliminary list of potentially inappropriate prescriptions as well as prescribing omissions in line with STOPP/START criteria (version 2) 20 ; and (3) medication optimization protocol-based team discussion; the deprescribing team reviewed the draft proposal and embarked on a step-by-step discussion, adhering to the medication optimization protocol; this discussion followed a specific algorithm, as proposed by Scott et al 11,19 : (1) assessment of medication indication; (2) balancing benefits and harms; (3) evaluation of symptomatic medications; and (4) evaluation of preventive medications. Following these steps, the medication optimization plan was explained and discussed with the participant or their next of kin.…”
Section: Trial Proceduresmentioning
confidence: 99%