Proton Beam Irradiation and Hyperthermia

Riedel, K. G.; Svitra, Paul P.; Seddon, Johanna M.; Albert, Daniel M.; Gragoudas, Evangelos S.; Koehler, Andreas; Coleman, D. Jackson; Torpey, J H; Lizzi, Frederic L.; Driller, J.

doi:10.1001/archopht.1985.01050120096028

Cited by 40 publications

(1 citation statement)

References 29 publications

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“…Protons supplemented with the high LET features of HT could mimic 12 C ion therapy and thus be a cost-effective alternative to 12 C ions (299-303) (Figure 4). Proton HTRT has shown promising results in experimental choroidal melanomas and inoperable large sacral chordomas (304,305). Presently proton HTRT is under investigation in inoperable soft tissue sarcoma (266,299).…”

Section: Opportunities: Hyperthermia With Protons and Use As Multifunctional Magnetic Nanoparticlesmentioning

confidence: 99%

Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses

et al. 2020

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Moderate hyperthermia at temperatures between 40 and 44 • C is a multifaceted therapeutic modality. It is a potent radiosensitizer, interacts favorably with a host of chemotherapeutic agents, and, in combination with radiotherapy, enforces immunomodulation akin to "in situ tumor vaccination." By sensitizing hypoxic tumor cells and inhibiting repair of radiotherapy-induced DNA damage, the properties of hyperthermia delivered together with photons might provide a tumor-selective therapeutic advantage analogous to high linear energy transfer (LET) neutrons, but with less normal tissue toxicity. Furthermore, the high LET attributes of hyperthermia thermoradiobiologically are likely to enhance low LET protons; thus, proton thermoradiotherapy would mimic 12 C ion therapy. Hyperthermia with radiotherapy and/or chemotherapy substantially improves therapeutic outcomes without enhancing normal tissue morbidities, yielding level I evidence reported in several randomized clinical trials, systematic reviews, and meta-analyses for various tumor sites. Technological advancements in hyperthermia delivery, advancements in hyperthermia treatment planning, online invasive and non-invasive MR-guided thermometry, and adherence to quality assurance guidelines have ensured safe and effective delivery of hyperthermia to the target region. Novel biological modeling permits integration of hyperthermia and radiotherapy treatment plans. Further, hyperthermia along with immune checkpoint inhibitors and DNA damage repair inhibitors could further augment the therapeutic efficacy resulting in synthetic lethality. Additionally, hyperthermia induced by magnetic nanoparticles coupled to selective payloads, namely, tumor-specific radiotheranostics (for both tumor imaging and radionuclide therapy), chemotherapeutic drugs, immunotherapeutic agents, and gene silencing, could provide a comprehensive tumor-specific theranostic modality akin to "magic (nano)bullets." To get a realistic overview of the strength (S), weakness (W), opportunities (O), and threats (T) of hyperthermia, a SWOT analysis has been undertaken. Additionally, a TOWS analysis Datta et al.Hyperthermia: SWOT and TOWS Analyses categorizes future strategies to facilitate further integration of hyperthermia with the current treatment modalities. These could gainfully accomplish a safe, versatile, and cost-effective enhancement of the existing therapeutic armamentarium to improve outcomes in clinical oncology.

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Section: Opportunities: Hyperthermia With Protons and Use As Multifunctional Magnetic Nanoparticlesmentioning

confidence: 99%

Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses

et al. 2020

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The Effect of Ocular Warming on Ocular Circulation in Healthy Humans

Nagaoka¹

2004

Arch Ophthalmol

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To examine the effect of ocular warming on retinal blood flow (RBF) and subfoveal choroidal blood flow (CBF) in humans. Methods: Ocular warming was induced in 10 healthy volunteers using an ocular warming lamp for 10 minutes. The ocular surface temperature was measured before and after warming. The RBF in the retinal artery and vein and the CBF in the foveal region were examined with a retinal laser Doppler velocimetry system and a laser Doppler flowmeter, respectively. Ocular blood flow measurements were performed before and 3, 6, and 9 minutes after warming. Results: The ocular surface temperature significantly increased just after warming and returned to baseline 10 minutes later. Three minutes after warming, the mean±SE RBF significantly increased in the retinal artery (14.2%±3.5%, P=.01) and vein (15.8%±3.6%, P=.006). Six minutes after warming, the RBF returned to baseline in the artery and vein. Three and 6 minutes after warming, the mean±SE CBF significantly decreased 16.6%±4.2% and 24.2%±4.7%, respectively (P=.001 for both). Nine minutes after warming, the measurements returned to baseline. Conclusions: The RBF increased and the CBF decreased in the foveal region after cessation of ocular warming in healthy young volunteers. The CBF in the foveal region may contribute to maintaining a constant retinal temperature in response to ocular warming.

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