Proton-pump inhibitors can decrease gastrointestinal bleeding after percutaneous coronary intervention

Jiang, Ziyan; Wu, Hao; Duan, Zhaotao; Wang, Zhibing; Hu, Kewei; Ye, Fei; Zhang, Zhenyu

doi:10.1016/j.clinre.2013.03.011

Cited by 13 publications

(13 citation statements)

References 26 publications

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“…Cox regression analysis adjusting for age, drinking and smoking, and previous peptic injury finds that PPI treatment is an effective prevention against serious GI complications. The result is consistent with several studies[11] [23], which found that co-prescription with PPI can significantly reduce the risk of GI bleeding. It might because that PPI inhibits gastric acid secretion and thus reduces the PH value of the stomach to prevent mucosal damage and bleeding and other complications induced by DAPT[29].…”

supporting

confidence: 92%

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Risk Factors for Gastrointestinal Injuries in Acute Coronary Syndrome Patients with Double Antiplatelet Therapy in One-Year Follow-Up

Zhong¹,

Chen²,

Zhang³

et al. 2018

WJCD

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Background: The goal is to determine the incidence of symptomatic gastrointestinal (GI) injuries in acute coronary syndrome (ACS) patients receiving double antiplatelet therapy (DAPT). The risk factors for serious GI complications are also evaluated. Methods: 603 eligible patients from the Department of Cardiology at Zhongda Hospital between January 2014 and August 2015 were enrolled and the occurrence of GI injuries within one year assessed. The risk factors for serious GI complications were identified using cox regression analysis. Results: After one-year follow-up, 108 (17.9%) out of 603 patients developed symptomatic GI injuries: 22 (3.65%) with serious GI complications and 86 (14.2%) with GI symptoms. Drinking habit (95% CI: 1.512-8.796; P = 0.004) and previous peptic injury (95% CI: 2.307-18.080; P = 0.001) are independent predictors of serious GI complications, while proton pump inhibitor (PPI) was protective (95% CI: 0.120-0.699; P = 0.006) per cox regression analysis. Additionally, GI injuries of both serious GI complications and GI symptoms peaked in the first three months. Conclusions: Symptomatic GI injuries were relatively common in ACS patients with DAPT, especially in the first three months. Previous peptic injury and drinking habit were significant independent risk factors for serious GI complications, while PPI played a protective role in ACS with DAPT.

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supporting

confidence: 92%

“…other research reported HR of 3.270 and 4.155 [23] [24]. It can be explained that previous studies focused on simple GI bleeding, while the end points of ulcer, pyloric obstruction, perforation, and death are included in ours, which led to a higher incidence in our study.…”

Section: Discussionmentioning

confidence: 66%

Risk Factors for Gastrointestinal Injuries in Acute Coronary Syndrome Patients with Double Antiplatelet Therapy in One-Year Follow-Up

Zhong¹,

Chen²,

Zhang³

et al. 2018

WJCD

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“…With portal vein and gastric vein congestion, upper gastrointestinal bleeding appears. Three studies reported previous bleeding was positively significantly associated with GIB (Jiang et al, ; Kikkert et al, ; Ko et al, ), leading mainly to rebleeding.…”

Section: Discussionmentioning

confidence: 99%

“…As shown above, gastrointestinal diseases are associated with smoking and drinking. Chronic renal failure is one of the causes of anaemia, with findings by Girndt (2017) (Jiang et al, 2013;Kikkert et al, 2015;Ko et al, 2010), leading mainly to rebleeding.…”

Section: Disease Risk Factorsmentioning

confidence: 99%

Meta‐analysis of risk and protective factors for gastrointestinal bleeding after percutaneous coronary intervention

Wang

Ouyang

et al. 2018

Int J of Nursing Practice

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Aim To quantitatively analyse factors related to gastrointestinal bleeding after percutaneous coronary intervention and provide evidence for the prevention of gastrointestinal bleeding. Data Sources and Review Methods Cochrane Library, Pubmed, Embase, and Ovid databases were searched from inception to 31 May 2018; case‐control and cohort studies published in English were included. The methodological quality of each study was assessed by two independent reviewers using the Newcastle‐Ottawa Scale. Meta‐analysis was performed using Revman version 5.3. Results A total of 16 publications yielded data about risk factors. It was found that age older than 70 years, age (per 10‐year increase), female sex, baseline anaemia, history of smoking, history of using alcohol, history of peptic ulcer disease, chronic renal failure, previous bleeding, shock, congestive heart failure, acute myocardial infarction, prior use of inotropic medications, and prior use of antithrombotic medications were positively associated with gastrointestinal bleeding. Four articles yielded data about protective factors. It was found that proton‐pump inhibitor and bivalirudin therapy were negatively associated with gastrointestinal bleeding after percutaneous coronary intervention. Conclusion This research found risk and protective factors which can assist in effective management of this potentially fatal complication.

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“…Previous studies have shown that the incidence of GIB after PCI ranges from 0.6% to 2.3% in the general population with very limited data in patients with cirrhosis [1]. Due to portal hypertension and bleeding disorders, patients with cirrhosis are at increased risk for severe GIBs compared to the general population [2,3].…”

Section: Introductionmentioning

confidence: 99%

The Morbidity and Mortality Risks following Percutaneous Coronary Interventions in Cirrhosis

Al-Azzawi¹,

Al-Abboodi²,

Fasullo³

et al. 2017

J Liver

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Proton-pump inhibitors can decrease gastrointestinal bleeding after percutaneous coronary intervention

Cited by 13 publications

References 26 publications

Risk Factors for Gastrointestinal Injuries in Acute Coronary Syndrome Patients with Double Antiplatelet Therapy in One-Year Follow-Up

Risk Factors for Gastrointestinal Injuries in Acute Coronary Syndrome Patients with Double Antiplatelet Therapy in One-Year Follow-Up

Meta‐analysis of risk and protective factors for gastrointestinal bleeding after percutaneous coronary intervention

The Morbidity and Mortality Risks following Percutaneous Coronary Interventions in Cirrhosis

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