Proton Pump Inhibitors for Functional Dyspepsia

Kane, Terri D

doi:10.1097/sga.0000000000000486

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“…Chronic kidney disease (CKD) is characterized by progressive biochemical and physiological deteriorations that affect body systems (1) . Unfortunately, the use of drugs that were considered safe has been detected as a possible cause of renal damage (2) . Among these drugs, proton pump inhibitors (PPI) which are highly prescribed worldwide shown to be associated with the occurrence of acute interstitial nephritis, reduction of glomerular filtration rate and the development of CKD (3) .…”

Section: Introductionmentioning

confidence: 99%

Reno-protective Role of Ginseng in Counteracting the Long-term Omeprazole Induced Adverse Effects in Albino Rats via Modulation of Inflammation, Apoptosis and Fibrosis

Maher

El‐Tahawy

Hussien

et al. 2023

Minia Journal of Medical Research

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Background: Omeprazole has long-term use adverse effects even though are commonly used.The study aimed at evaluation of the possible renal protective effect of ginseng against the long-term omeprazole-induced adverse effects. Methods: Forty albino rats were divided into: C group (control), G group (ginseng), OM group (omeprazole) and OM-G group (omeprazole-ginseng). Renal functions and histological renal tissues were investigated. Results: The OM group had significantly high levels of urea, creatinine and 24-hours protein urea. A significant glomerular, tubular and interstitial injury was observed; congestion, inflammatory cell infiltration, tubular damage, increased collagen deposition and significant increases in COX-2 and caspase-3 immune expression. While adding ginseng with omeprazole resulted in marked improvement in these changes. Conclusion: Long-term use of omeprazole induced renal functional and morphological changes through induction of inflammatory reaction, fibrosis, cellular degeneration and apoptosis. By adding ginseng, these effects were ameliorated through its anti-fibrotic, anti-inflammatory, and anti-apoptotic effects.

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Section: Introductionmentioning

confidence: 99%