Proton therapy needs further technological development to fulfill the promise of becoming a superior treatment modality (compared to photon therapy)

Hyer, Daniel E.; Ding, Xuanfeng; Rong, Yi

doi:10.1002/acm2.13450

Cited by 6 publications

(4 citation statements)

References 78 publications

(95 reference statements)

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“…With technological advances in online imaging, proton therapy can achieve its full clinical potential and may prove to be a valuable treatment modality when delivering prostate SBRT. 19 …”

Section: Discussionmentioning

confidence: 99%

The Status and Challenges for Prostate Stereotactic Body Radiation Therapy Treatments in United States Proton Therapy Centers: An NRG Oncology Practice Survey

Shen,

Taylor,

Vargas

et al. 2024

International Journal of Particle Therapy

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“…With technological advances in online imaging, proton therapy can achieve its full clinical potential and may prove to be a valuable treatment modality when delivering prostate SBRT. 19 …”

Section: Discussionmentioning

confidence: 99%

The Status and Challenges for Prostate Stereotactic Body Radiation Therapy Treatments in United States Proton Therapy Centers: An NRG Oncology Practice Survey

Shen,

Taylor,

Vargas

et al. 2024

International Journal of Particle Therapy

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“…While the costly infrastructure of FLASH-proton is the primary ongoing challenge for implementing the FLASH-proton, the energy deposition of proton in Bragg-Peak (BP) and using it for deep-seated tumors made this method so interesting to investigate [80]. The finite range of protons that causes low-dose radiation bath and consequently minimizes the second cancer risk is the effectiveness of the FLASH-proton [85]. However, some biological uncertainties in proton therapy are disadvantages of this technology, and future studies in proton therapy will investigate DNA damage in FLASH-proton [86].…”

Section: Flash-protonmentioning

confidence: 99%

FLASH Radiation Therapy — Key physical irradiation parameters and beam characteristics

Boudaghi Malidarreh,

Zakaly

2024

J. Inst.

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FLASH-RT represents a novel therapeutic radiation modality that holds remarkable potential for mitigating radiation therapy's adverse side effects. This cutting-edge technology allows for sparing healthy tissue while precisely targeting cancerous cells. This is possible by administering an ultra-high-dose-rate in less than a few hundred milliseconds. FLASH-RT has demonstrated impressive results in small-animal models, prompting scientists to adapt and advance existing technologies to make it a viable treatment option for humans. However, producing the ultra-high-dose-rate radiation required for the therapy remains a significant challenge. Several radiation sources, such as very high energy electrons (VHEEs), low energy electrons, x-rays, and protons, have been studied for their ability to deliver the necessary dose. Among them, FLASH-x-ray has gained the most attention owing to its capacity to penetrate deep-seated tumors. Despite the complexity of the process, the potential advantages of FLASH-RT made it an exciting area of research. To achieve the FLASH effect, high-frequency, pulsed irradiated accelerator technology can be employed. Sparing healthy tissue may allow for more aggressive and effective cancer treatments, leading to a better quality of life for patients. Ongoing research and development will be necessary to refine and optimize this approach to radiation therapy.

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“…While the costly infrastructure of FLASH-proton is the primary ongoing challenge for implementing the FLASH-proton, the energy deposition of proton in Bragg-Peak (BP) and using for deep-seated tumours made this method so interesting to investigate [79]. The finite range of protons, and consequently elimination the exit dose, which causes low-dose radiation bath and consequently minimizing the second cancer risk is the effectiveness of the FLASH-proton [84]. However, some biological uncertainties in proton therapy are disadvantage of this technology and future study in proton will be investigation of DNA damage in proton therapy [85].…”

Section: Flash-protonmentioning

confidence: 99%

FLASH Radiation Therapy- Key Physical Irradiation Parameters and Beam Characteristics

boodaghi malidarre,

Zakaly

2023

Preprint

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FLASH-RT represents a novel therapeutic radiation modality that holds remarkable potential for mitigating radiation therapy’s adverse side effects. This cutting-edge technology allows for the sparing of healthy tissue while precisely targeting cancerous cells by administering an ultra-high dose-rates of typically between 10 and 30 Gy in less than a few hundred milliseconds. FLASH-RT has demonstrated impressive results in small-animal models, prompting scientists to adapt and advance existing technologies to make it a viable treatment option for humans. However, producing the ultra-high-dose-rate radiation required for the therapy remains a significant challenge. Several radiation sources, such as very high energy electrons (VHEEs), low energy electrons, x-rays, and protons, have been studied for their ability to deliver the necessary dose. Among them, FLASH-x-ray has gained the most attention owing to its capacity to penetrate deeply seated tumours. Despite the complexity of the process, the potential advantages of FLASH-RT make it an exciting area of research. To achieve the FLASH effect, high-frequency, pulsed irradiated accelerator technology can be employed. Sparing healthy tissue, it may allow for more aggressive and effective cancer treatments, leading to a better quality of life for patients. Ongoing research and development will be necessary to refine and optimize this approach to radiation therapy.

show abstract

Proton therapy needs further technological development to fulfill the promise of becoming a superior treatment modality (compared to photon therapy)

Cited by 6 publications

References 78 publications

The Status and Challenges for Prostate Stereotactic Body Radiation Therapy Treatments in United States Proton Therapy Centers: An NRG Oncology Practice Survey

The Status and Challenges for Prostate Stereotactic Body Radiation Therapy Treatments in United States Proton Therapy Centers: An NRG Oncology Practice Survey

FLASH Radiation Therapy — Key physical irradiation parameters and beam characteristics

FLASH Radiation Therapy- Key Physical Irradiation Parameters and Beam Characteristics

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