Providing Unique Support for Health Study Among Young Black and Latinx Men Who Have Sex With Men and Young Black and Latinx Transgender Women Living in 3 Urban Cities in the United States: Protocol for a Coach-Based Mobile-Enhanced Randomized Control Trial

Arrington‐Sanders, Renata; Hailey-Fair, Kimberly; Wirtz, Andrea L; Cos, Travis; Galai, Noya; Brooks, Durryle; Castillo, Marné; Dowshen, Nadia; Trexler, Connie; D’Angelo, Lawrence J.; Kwait, Jennafer; Beyrer, Chris; Morgan, Anthony; Celentano, David D.; Study, Push

doi:10.2196/17269

Cited by 18 publications

(10 citation statements)

References 86 publications

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“…Outside of HIV research, several large cohorts, such as the NIH's Precision Medicine Initiative Cohort [24] and the Black Women's Health Study [25], recruit and follow up to 1 million participants across the United States using predominantly technology-based methods. Technology is increasingly integrated into HIV research through sampling and recruitment methods via online advertisements on social media and dating apps as well as electronic peer referral methods [26,27]; electronic and remote data collection [28][29][30]; and remote specimen collection for biologic measures [31][32][33]. These tools have permitted enrollment of large samples of participants for behavioral surveys [34][35][36], cohort research [37][38][39], and intervention research [40,41].…”

Section: Introductionmentioning

confidence: 99%

Digital Epidemiologic Research on Multilevel Risks for HIV Acquisition and Other Health Outcomes Among Transgender Women in Eastern and Southern United States: Protocol for an Online Cohort

et al. 2021

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Background:The HIV epidemic disproportionately impacts transgender women in the United States. Cohort studies identify unique risks for affected populations, but use of facility-based methods may bias findings towards individuals living in research catchment areas, more engaged in health services, or, in the case of transgender populations, those who are open about their transgender identity. Digital clinical trials and other online research methods are increasingly common, providing opportunity to reach those not commonly engaged in research. Simultaneously, there is a need to understand potential biases associated with digital research, how these methods perform, and whether they are accepted across populations.Objective: This study aims to assess the feasibility of developing and implementing an online cohort of transgender women to assess risks for HIV acquisition and other health experiences. Further, this study aims to evaluate how an online cohort compares to a site-based, technology-enhanced cohort for epidemiologic research. The overarching goal is to estimate incidence of HIV and other health outcomes among transgender women in eastern and southern United States.

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Section: Introductionmentioning

confidence: 99%

Digital Epidemiologic Research on Multilevel Risks for HIV Acquisition and Other Health Outcomes Among Transgender Women in Eastern and Southern United States: Protocol for an Online Cohort

et al. 2021

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“…We also observed that peer-based interventions often incorporated personalized elements [ 34 , 38 , 55 , 56 ]. In a culturally-tailored counseling intervention, Black MSM interventionists helped participants identify and address their barriers to PrEP initiation (e.g., health insurance, mental health violence, alcohol and substance abuse) based on their prevention needs, and referred them to appropriate prevention resources [ 34 ].…”

Section: Resultsmentioning

confidence: 94%

“…Forty-two interventions were categorized into 5 socioecological levels and characteristics of interventions on each level are presented in Additional file 1 : Tables S1–S5, respectively. PrEP interventions for MSM were reported to implement in the US South (Florida, Georgia, Texas, Maryland, Mississippi, North Carolina and D.C.) [ 30 – 40 ], Northeast (Pennsylvania, New York, Massachusetts and Rhode Island) [ 27 , 31 – 33 , 36 , 38 , 41 – 49 ], Midwest (Illinois, Michigan, and Wisconsin) [ 24 – 26 , 32 , 33 , 36 , 47 , 50 – 52 ], West (California) [ 51 , 53 – 58 ] and nationwide [ 59 – 63 ]. Thirty-seven of the 42 studies focused solely on MSM [ 24 – 27 , 30 – 34 , 36 – 41 , 43 – 47 , 49 – 54 , 56 , 58 – 72 ], with some targeting Black, Hispanic/Latino MSM or MSM younger than 34 years old [ 24 – 27 , 30 – 34 , 36 – 40 , 44 – 46 , 49 , 50 , 52 , 56 , 58 , 60 – 63 , 70 ].…”

Section: Resultsmentioning

confidence: 99%

“…Access to PrEP was referred to participants’ linkage to healthcare system (e.g., scheduling or attending an appointment for PrEP consultation) [ 25 , 27 , 33 – 35 , 39 , 52 , 58 , 69 – 71 ]. PrEP uptake was measured by self-reported PrEP initiation or a recipient of a prescription for PrEP [ 25 , 30 , 31 , 34 – 36 , 38 , 39 , 43 – 46 , 52 , 54 , 55 , 57 , 58 , 60 , 69 – 72 ]. Adherence to PrEP utilized both behavioral (e.g., self-reported retention in PrEP care or number of doses missed in the past 30 days) [ 30 – 33 , 36 , 40 , 46 , 48 – 51 , 58 , 60 , 73 ] or biological measurements (e.g., PrEP concentration in dried blood spots) [ 24 , 32 , 33 , 37 , 40 – 42 , 53 , 72 ].…”

Section: Resultsmentioning

confidence: 99%

“…Motivational interviewing (MI) was another common strategy applied in peer-based interventions. Peer mentors would use MI to help MSM resolve their ambivalence about behavioral change as they moved through the different stages of change (e.g., contemplation, determination and action) [ 38 , 55 , 56 ]. In an ongoing coach-based, mobile-enhanced intervention, participants who reported barriers to telephonic engagement in HIV prevention services would be connected with peer coaches, who would empathize with them and assist by exploring alternative means to help retain them in the study [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

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Evidence and implication of interventions across various socioecological levels to address pre-exposure prophylaxis uptake and adherence among men who have sex with men in the United States: a systematic review

et al. 2022

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Background Pre-exposure prophylaxis (PrEP) represents a proven biomedical strategy to prevent HIV transmissions among men who have sex with men (MSM) in the United States (US). Despite the design and implementation of various PrEP-focus interventions in the US, aggregated evidence for enhancing PrEP uptake and adherence is lacking. The objective of this systematic review is to synthesize and evaluate interventions aimed to improve PrEP uptake and adherence among MSM in the US, and identify gaps with opportunities to inform the design and implementation of future PrEP interventions for these priority populations. Methods We followed the PRISMA guidelines and conducted a systematic review of articles (published by November 28, 2021) with a focus on PrEP-related interventions by searching multiple databases (PubMed, MEDLINE, Web of Science and PsycINFO). Details of PrEP interventions were characterized based on their socioecological level(s), implementation modalities, and stage(s) of PrEP cascade continuum. Results Among the 1363 articles retrieved from multiple databases, 42 interventions identified from 47 publications met the inclusion criteria for this review. Most individual-level interventions were delivered via text messages and/or apps and incorporated personalized elements to tailor the intervention content on participants’ demographic characteristics or HIV risk behaviors. Interpersonal-level interventions often employed peer mentors or social network strategies to enhance PrEP adoption among MSM of minority race. However, few interventions were implemented at the community-, healthcare/institution- or multiple levels. Conclusions Interventions that incorporate multiple socioecological levels hold promise to facilitate PrEP adoption and adherence among MSM in the US given their acceptability, feasibility, efficacy and effectiveness. Future PrEP interventions that simultaneously address PrEP-related barriers/facilitators across multiple socioecological levels should be enhanced with a focus to tackle contextual and structural barriers (e.g., social determinants of health, stigma or medical mistrust) at the community- and healthcare/institution-level to effectively promote PrEP use for MSM of color.

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An evaluation of assumptions underlying respondent‐driven sampling and the social contexts of sexual and gender minority youth participating in HIV clinical trials in the United States

et al. 2021

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Introduction: Respondent-driven sampling (RDS) has been an effective sampling strategy for HIV research in many settings, but has had limited success among some youth in the United States. We evaluated a modified RDS approach for sampling Black and Latinx sexual and gender minority youth (BLSGMY) and explored how lived experiences and social contexts of BLSGMY youth may impact traditional RDS assumptions. Methods: RDS was implemented in three US cities, Baltimore, Philadelphia and Washington DC, to engage BLSGMY aged 15 to 24 years in HIV prevention or care intervention trials. RDS was modified to include targeted seed recruitment from venues, Internet and health clinics, and provided options for electronic or paper coupons. Qualitative interviews were conducted among a sub-sample of RDS participants to explore their experiences with RDS. Interviews were coded using RDS assumptions as an analytic framework. Results: Between August 2017 and October 2019, 405 participants were enrolled, 1670 coupons were distributed, with 133 returned, yielding a 0.079 return rate. The maximum recruitment depth was four waves among seeds that propagated. Selfreported median network size was 5 (IQR 2 to 10) and reduced to 3 (IQR 1 to 5) when asked how many peers were seen in the past 30 days. Qualitative interviews (n = 27) revealed that small social networks, peer trust and targeted referral of peers with certain characteristics challenged network, random recruitment, and reciprocity assumptions of RDS. HIV stigma and research hesitancy were barriers to participation and peer referral. Other situational factors, such as phone ownership and access to reliable transportation, reportedly created challenges for referred peers to participate in research. Conclusions: Small social networks and varying relationships with peers among BLSGMY challenge assumptions that underlie traditional RDS. Modified RDS approaches, including those that incorporate social media, may support recruitment for community-based research but may challenge assumptions of reciprocal relationships. Research hesitancy and situational barriers are relevant and must be addressed across any sampling method and study design that includes BLSGMY in the United States.

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Providing Unique Support for Health Study Among Young Black and Latinx Men Who Have Sex With Men and Young Black and Latinx Transgender Women Living in 3 Urban Cities in the United States: Protocol for a Coach-Based Mobile-Enhanced Randomized Control Trial

Cited by 18 publications

References 86 publications

Digital Epidemiologic Research on Multilevel Risks for HIV Acquisition and Other Health Outcomes Among Transgender Women in Eastern and Southern United States: Protocol for an Online Cohort

Digital Epidemiologic Research on Multilevel Risks for HIV Acquisition and Other Health Outcomes Among Transgender Women in Eastern and Southern United States: Protocol for an Online Cohort

Evidence and implication of interventions across various socioecological levels to address pre-exposure prophylaxis uptake and adherence among men who have sex with men in the United States: a systematic review

An evaluation of assumptions underlying respondent‐driven sampling and the social contexts of sexual and gender minority youth participating in HIV clinical trials in the United States

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