Proxyphylline release kinetics from symmetrical three-layer silicone rubber matrices: Effect of different excipients in the outer rate-controlling layers

Permeation Study of Indomethacin from Polycarbazole/Natural Rubber Blend Film for Electric Field Controlled Transdermal Delivery

“…After the permeation study, the pores were then generated on surface of DCNR film, consistent with a previous study. 33 In an absence of an electric field, a surface showed quite irregular pore surface, whereas for the film with electric field a highly dispersed pores occurred throughout the surface. 5 The results of pore formation convincingly suggest that the increase pore formation can be directly related to increase the amount of IN permeation and the diffusion coefficient.…”

Rubber Polymers for Transdermal Drug Delivery Systems

“…For example, Soulas et al used silicone rubber in the design strategy of multilayer matrixes, which exhibited improved release performance in relation to their monolithic counterparts. The symmetrical three-layers of silicone rubber matrixes consisted of an inner drug-containing layer, proxyphylline loaded into a silicone rubber matrix embedded between two silicone rubber matrix layers, and PEG, a hydrophilic polymeric excipient …”

“…consisted of an inner drug-containing layer, proxyphylline loaded into a silicone rubber matrix embedded between two silicone rubber matrix layers, and PEG, a hydrophilic polymeric excipient. 66 The recent improvement and development of rubber polymer selection and design are of great importance in meeting the various criteria of new transdermal drug delivery systems, including patches, gel, and film forming polymeric solutions. The two types of rubber polymers: natural rubber and synthetic rubber together with the physicochemical properties of the pharmacologically active drug should be well considered, and the rubber polymer's biocompatibility, especially with the skin is significant.…”

Drug release from slabs and the effects of surface roughness

“…A few recent examples report: nanostructured films exhibiting lysozyme-controlled release of EGF for wound-healing applications [1], sol-gel silica thin films providing efficient local delivery of antibiotics with adjuvant for potential inhibition of bacterial infection in titanium implants [2], multilayered films sequentially releasing multiple drugs for periodontitis treatment [3], multilayers showing suppression of burst release and an adjustable release rate regulated by the composition and the relative thickness of the layers [4], etc.…”