2010
DOI: 10.1002/dvdy.22305
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Prrxl1 is required for the generation of a subset of nociceptive glutamatergic superficial spinal dorsal horn neurons

Abstract: Perception of noxious events relies on activation of complex central neuronal circuits. The spinal cord dorsal horn plays a pivotal role in the process relaying to the brain various types of somatosensory input. These functions are accomplished by distinct sensory neurons specifically organized in different laminae. They differentiate during development in a spatial-temporal order due to the expression of combinatorial sets of homeodomain transcription factors. Here we demonstrate that the differential express… Show more

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Cited by 30 publications
(35 citation statements)
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References 48 publications
(82 reference statements)
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“…This study addresses the transcriptional control mechanisms of Prrxl1, a homeobox gene critical for proper assembly of DRG-dorsal SC pain circuitry [5,20,22]. ChIP performed with chromatin derived from embryonic DRG and dorsal SC identified two regions (in the proximal promoter and intron 4 of Prrxl1 locus) that show tissue specific recruitment of Prrxl1.…”
Section: Discussionmentioning
confidence: 99%
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“…This study addresses the transcriptional control mechanisms of Prrxl1, a homeobox gene critical for proper assembly of DRG-dorsal SC pain circuitry [5,20,22]. ChIP performed with chromatin derived from embryonic DRG and dorsal SC identified two regions (in the proximal promoter and intron 4 of Prrxl1 locus) that show tissue specific recruitment of Prrxl1.…”
Section: Discussionmentioning
confidence: 99%
“…In the DRG, the pan-sensory HD transcription factors Pou4f1 and Isl1 are both required for Prrxl1 expression [11]. On the other hand, in developing dorsal SC, Tlx1/ 3 and Lmx1b are extensively co-expressed with Prrxl1 [22,23]. Prrxl1 appears to depend more on Lmx1b than on Tlx1/3, as in Lmx1b null mice Prrxl1 expression was completely abolished [9], whereas in Tlx1/3 null mutant mice Prrxl1 expression was normally initiated but completely lost by E14.5 [19].…”
Section: Discussionmentioning
confidence: 99%
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“…It would be interesting to assess if one possible RRB binding candidate could be Tlx3 as this transcription factor induces Prrxl1 promoter activity (Fig. 7A) and highly co-localizes with Prrxl1 (10).…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, the role of Prrxl1 in these tissues is poorly studied. Prrxl1 null mutant mice present a distorted spinal dorsal horn with scarce superficial nociceptive-responsive neurons (8 -10), reduced DRG neuronal population (10), and a marked decrease in nociceptive response capacity in various pain tests (8). Interestingly, although involved in the embryonic differentiation of various subpopulations of superficial dorsal horn excitatory neurons (10), Prrxl1 appears not to be required for the normal development of DRG neurons before birth but rather to be essential for their survival in early postnatal life (9).…”
mentioning
confidence: 99%