PRSS23 (Serine Protease 23) is required for the progression of gastric cancer

Abstract

PRSS23 (Serine Protease 23) is a vital serine protease that is related to various types of cancers. However, the correlation between PRSS23 and gastric cancer remains unclear. In our study, our objective is to identify the key biomarkers and signaling pathways by analyzing the RNA-seq data. The GSE204725 was created by the Illumina HiSeq 4000 (Homo sapiens). The gene enrichment study indicated the cAMP signaling pathway and Calcium signaling pathway are the main biological processes during the knockdown of PRSS23 in gastric cancer. Moreover, we identified several interactive genes including NCAM1, HIST1H2BD, VWF, HIST1H2BL, GATA1, RYR2, CHRD, PDE4B, HIST1H4B, and HIST2H4B. Our study may provide new knowledge on the treatment of gastric cancer.