Pruritus in patients with solid tumors: an overlooked supportive care need

Vallely, Jaxon; Hudson, Kathryn Elizabeth; Locke, Susan C.; Wolf, Steven; Samsa, Gregory P.; Abernethy, Amy Pickar; LeBlanc, Thomas W.

doi:10.1007/s00520-019-04693-5

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…Although pruritus in DM patients is not a direct threat to patients' lives, it has a serious impact on patient's quality of life and physical and mental health, reduces patients' compliance with treatment and is detrimental to the control of their condition, thus increasing their long-term mortality ( 10 , 11 ). In recent years, there has been an increasing number of research treatments for pruritus in patients with MD, but with little success ( 12 , 13 ). Therefore, analysis of the causes of pruritus in DM patients, establishment of a suitable assessment system, and interventions targeting them to evaluate the effects of interventions have great clinical and social significance in improving the quality of life of DP patients.…”

Section: Introductionmentioning

confidence: 99%

Major Risk Factors Analysis of Pruritus Complicated by Type 2 Diabetes Mellitus and the Effect of Comprehensive Nursing Intervention

Yang

Chen

et al. 2022

Front. Surg.

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ObjectiveTo observe the main risk factors for pruritic skin evidence complicating type 2 diabetes mellitus (T2DM) and the effectiveness of interventions with comprehensive care measures.MethodsTwo hundred and twenty four patients with T2DM admitted to our hospital from June 2020 to November 2021 were selected and divided into Diabetic pruritus group (DP group, n = 71) and T2DM group (n = 153) according to the patients' complications of pruritus. General information such as gender, age, body mass index (BMI), duration of illness, family history, treatment modalities, other comorbidities, underlying illnesses were collected from all patients. Fasting plasma glucose (FPG), renal function [Serum creatinine (Scr), urea nitrogen (BUN), uric acid (BUA)], lipid levels [total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)] were measured in all patients on day 2 after admission. Risk factors for pruritus complicating T2DM were identified by single multifactorial analysis. Meanwhile, patients in the DP group were divided into group A (n = 35) and group B (n = 36) using the random number table method. Group A adopted the conventional care mode and group B patients adopted the comprehensive care interventions to compare the care effects [visual analog score (VAS) before and after care, treatment efficiency, care satisfaction rate] of patients in groups A and B; the levels of pruritus mediator indicators [substance P,β-endorphin (β-EP) and γ-interferon (INF-γ)] before and after care.ResultsRisk factors for pruritus in T2DM were age, duration of DM, combined Diabetic peripheral neuropathy (DPN), combined diabetic retinopathy (DR), combined diabetic kidney disease (DKD) and serum FPG levels (P <0.05). Satisfaction rate of nursing care, treatment efficiency, post-care improvement in VAS scores, serum substance P, β-EP and INF-γ levels and other mediators of pruritus were better in Group B with integrated nursing intervention than in group A with conventional care only (P < 0.05).ConclusionPruritus in T2DM is associated with age, duration of DM, combined DPN, combined DR, combined DKD and FPG levels. Comprehensive care according to the above risk factors can effectively relieve patients' clinical symptoms and signs, improve the level of pruritus mediators and patient-care relationship.

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Section: Introductionmentioning

confidence: 99%

Major Risk Factors Analysis of Pruritus Complicated by Type 2 Diabetes Mellitus and the Effect of Comprehensive Nursing Intervention

Yang

Chen

et al. 2022

Front. Surg.

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“…Although we could imagine that pruritus might be more of a problem in subjects on lower-dose, long-term treatments with conventional chemotherapy, a clinically relevant amount of pruritus may be observed among patients getting new treatments such as targeted therapy [158].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Immunological Checkpoint Inhibitors and Targeted Therapy on Chronic Pruritus in Cancer Patients

et al. 2020

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Although pruritus may sometimes be a consequential situation to neoplasms, it more frequently emerges after commencing chemotherapy. In this review, we present our analysis of the chemotherapy treatments that most often induce skin changes and itching. After discussing conventional chemotherapies capable of inducing pruritus, we present our evaluation of new drugs such as immunological checkpoint inhibitors (ICIs), tyrosine kinase inhibitors, and monoclonal antibodies. Although ICIs and targeted therapy are thought to damage tumor cells, these therapies can modify homeostatic events of the epidermis and dermis, causing the occurrence of cutaneous toxicities in treated subjects. In the face of greater efficacy, greater skin toxicity has been reported for most of these drugs. A remarkable aspect of some reports is the presence of a probable correlation between cutaneous toxicity and treatment effectiveness in tumor patients who were treated with novel drugs such as nivolumab or pembrolizumab. Findings from these experiments demonstrate that the occurrence of any grade of skin side effects can be considered as a predictor of a better outcome. In the near future, studies on the relationship between the onset of skin alterations and outcomes could open new perspectives on the treatment of neoplasms through specific target therapy.

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“… 1 Pruritus is a substantial symptom of hematologic malignancies, 1 , 2 and to a lesser extent, solid tumors. 1 , 3 …”

Section: Introductionmentioning

confidence: 99%

Dupilumab for cancer-associated refractory pruritus

Talmon¹,

Elias²,

Rubin³

et al. 2023

Journal of Allergy and Clinical Immunology: Global

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Pruritus in patients with solid tumors: an overlooked supportive care need

Cited by 4 publications

References 38 publications

Major Risk Factors Analysis of Pruritus Complicated by Type 2 Diabetes Mellitus and the Effect of Comprehensive Nursing Intervention

Major Risk Factors Analysis of Pruritus Complicated by Type 2 Diabetes Mellitus and the Effect of Comprehensive Nursing Intervention

The Impact of Immunological Checkpoint Inhibitors and Targeted Therapy on Chronic Pruritus in Cancer Patients

Dupilumab for cancer-associated refractory pruritus

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