Pruritus may be a common symptom related to neuromyelitis optica spectrum disorders

He, Zelai; Ren, Ming; Guo, Q F; Qi, Xiaokun

doi:10.1016/j.msard.2017.01.011

Cited by 18 publications

(22 citation statements)

References 18 publications

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“…Painful paroxysmal tonic spasms are also more common in AQP4-IgG seropositive NMOSD than in MS. 18 Pruritis may accompany or precede an attack of myelitis, typically in the dermatomal distribution affected by the myelopathy. 19 Intractable nausea, vomiting, or hiccups from area postrema involvement of AQP4-IgG seropositive NMOSD may precede or coexist with a myelitis attack, particularly the first episode, and may be a clue to this diagnosis. A thorough review of other prior or concurrent symptoms typical of AQP4-IgG seropositive NMOSD (e.g., severe and/or bilateral optic neuritis, brainstem/diencephalic/cerebral syndrome) 14 can be very supportive of the underlying diagnosis.…”

Section: Aquaporin-4-igg Seropositive Neuromyelitis Optica Spectrum Dmentioning

confidence: 99%

Autoimmune and Paraneoplastic Myelopathies

Zalewski

Flanagan

2018

Semin Neurol

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Prompt recognition of an inflammatory myelopathy is critical, as a specific diagnosis and management plan allows for optimal patient outcomes. Many treatment options are now available for autoimmune and paraneoplastic myelopathies, but specific management strategies and expected prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information that can help achieve a specific myelopathy diagnosis and treatment plan is essential for all neurologists, given the variety of contexts in which myelopathies are encountered. We provide an outline of the diagnostic evaluation and treatment of various inflammatory myelopathies seen in autoimmune and paraneoplastic diseases, including multiple sclerosis, aquaporin-4 immunoglobulin G (IgG) seropositive neuromyelitis optica spectrum disorder, sarcoidosis, myelin oligodendrocyte glycoprotein IgG associated disease, and other rare inflammatory myelopathies; we also highlight common mimickers of inflammatory myelopathies.

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Section: Aquaporin-4-igg Seropositive Neuromyelitis Optica Spectrum Dmentioning

confidence: 99%

Autoimmune and Paraneoplastic Myelopathies

Zalewski

Flanagan

2018

Semin Neurol

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“…Hence, this may indicate a new episode of myelitis in patients with NMOSD. 77 , 78 Although it has only been supported by case reports so far, intractable pruritus could be an underestimated characteristic feature of NMOSD. Several possible mechanisms could explain intractable pruritus as a symptom in patients with NMOSD.…”

Section: The Complexity and Wide Range Of Nmosdmentioning

confidence: 99%

Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations

Han

Yang

Zhu

2017

NDT

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Neuromyelitis optica (NMO), considered to be mediated by autoantibodies, often cause severely disabling disorders of the central nervous system, and predominantly cause optic nerve damage and longitudinally extensive transverse myelitis. Remarkable progress has been made in deciphering NMO pathogenesis during the past decade. In 2015, the International Panel for NMO Diagnosis proposed the unifying term “NMO spectrum disorders” (NMOSD) and the updated NMOSD criteria reflects a wide range of disease and maintains reasonable specificity. Moreover, cumulative findings have indicated that NMOSD are frequently associated with multiple autoimmune diseases, thereby presenting complex clinical symptoms that make this disease more difficult to recognize. Notably, most neurologists do not heed these symptoms or comorbid conditions in patients with NMOSD. Whereas previous reviews have focused on pathogenesis, treatment, and prognosis in NMOSD, we summarize the present knowledge with particular emphasis on atypical manifestations and autoimmune comorbidities in patients with NMOSD. Furthermore, we emphasized the identification of these atypical characteristics to enable a broader and better understanding of NMOSD, and improve early accurate diagnosis and therapeutic decision making.

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“…Pruritus was noted to be common in patients with NMO, and described in frequencies between 26.3 and 64.4% of the cohorts (Elsone et al, 2013;Xiao et al, 2016Netravathi et al, 2017He et al, 2017). Elsone et al (2013) was the first to describe it in 2013, with a prevalence of 27.3% within a week of other symptoms of TM: 25% of this sample had the symptom as their first manifestation of myelitis (first or relapses).…”

Section: "Non-motor" Symptoms In Nmomentioning

confidence: 94%

“…We specifically inquired patients about areas of consistent pruritus and not just random eventual itchiness related to dry skin, allergies of bug bites. Different studies have reported this symptom in NMO and described frequencies between 26.3 and 64.4% of the cohorts (Elsone et al, 2013;Xiao et al, 2016;Netravathi et al, 2017;He et al, 2017). Elsone et al (2013) reported that one fourth of NMO patients had pruritus preceding any other motor or sensory disturbance as an onset symptom.…”

Section: Graphic 4 -Changes In Edss (A) Bpi Intensity (B) Bpi Intermentioning

confidence: 99%

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Caracterização do perfil de síndromes dolorosas, psicofísica e medidas de excitabilidade cortical em doentes com neuromielite óptica controlada

Silva¹

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DEDICATÓRIAAo meus pais, Carmélio e Solange, por seu exemplo de resiliência e carinho em todas as etapas da minha vida.Aos meus irmãos, Adriana e Fabio, por terem me ensinado quase tudo que sou hoje. Ao meu marido e namorado Yuri, por ter dedicado a mim tamanho amor incondicional (e paciência).Esta tese está de acordo com as seguintes normas, em vigor no momento desta publicação: Referências: adaptado de International

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Pruritus may be a common symptom related to neuromyelitis optica spectrum disorders

Cited by 18 publications

References 18 publications

Autoimmune and Paraneoplastic Myelopathies

Autoimmune and Paraneoplastic Myelopathies

Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations

Caracterização do perfil de síndromes dolorosas, psicofísica e medidas de excitabilidade cortical em doentes com neuromielite óptica controlada

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