Ps-C10-12: How Is the Estimated Glomerular Filtration Rate Distributed by Association of the Most Common Cardiovascular Risk Factors in Diabetic Patients?

Abstract

Objective:This study aims to characterize the distribution of estimated glomerular filtration rate (eGFR) in diabetic patients by association of common cardiovascular risk factors (CVRF) known as alcohol abuse (P15), tobacco abuse (P17), dyslipidemia (T93) and LDL cholesterol value, body mass index (BMI) and systolic blood pressure (sBP).Design/method:Cross-sectional, descriptive and analytical study. Anonymized data were obtained from users of 20 medical files who had at least one medical appointment, with at least one record of sBP, LDL, BMI and creatinine in the last 3 years until the 31st December 2021. The studied variables were sex, age, weight, BMI, creatinine, eGFR(CKD-EPI formula), target organ damage (TOD) identified by the existence of the following ICPC-2 coding: K74, K75, K76, K87 or K89, K90, K91 or K92; hypertension (K86 or K87), diabetes (T89 or T90), P15, P17, T93, at the date of the last record under study. For data collection, it was used MIM@UF®; program and the statistical analysis was performed using the R®3.6.3 program.Cardinality diagrams were created to show the association of CVRF and eGFR, CVRF and sBP, TOD type and sBP. A prediction model for the event of eGFR< 60 mL/min/1.73m2 was also created through a logistic regression model that links the occurrence of chronic kidney disease (CKD) with the predictors HTA, Diabetes, TOD, P15, P17 and T93.Results:The convenience sample consisted of 2396 diabetics, of which 1214 were male, and whose mean age was 70 years (IQR = 17 years). It was found that 70% have coded T93, 79% have hipertension, 38% are obese and 19% have TOD. The most frequent association of CVRF is HTA and T93 with 961 diabetics, followed by HTA with 373 diabetics.The logistic regression model shows that CVRF in diabetic patients in association with CKD, there are two variables that have statistical significance (age and hypertension). So, a constant 1 year increment in age increases the chance of finding a patient with CKD by 10% and the chance of a diabetic patient having CKD while being hypertensive is 2.59 times higher than a normotensive diabetic patient.Conclusions:The presence of several CVRF is frequent in the population that was studied, and the identification and understanding of their distribution is essential for an adequate management of diabetes. CKD is a frequent complication in these patients, and regular evaluation of eGFR and the other CVRF is essential for proper therapeutic management.