2019
DOI: 10.1097/01.hs9.0000563688.92294.ec
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Ps1352 Dissecting the Bone Marrow Immune Microenvironment in the Complete Spectrum of Monoclonal Gammopathies: Potential Implications in Disease Pathogenesis

Abstract: respectively BCL2 and MCL1. We also intended to decipher the mechanism of action of this combination and to identify resistance factors. Methods: For this study, we treated a panel of 25 Human Myeloma cell lines (HMCLs) and a cohort of more than 40 myeloma patient samples with Venetoclax and S63845 to identify those resistant to both agents. This group of resistant HMCLs and patient samples was treated with the combination S63845/Venetoclax at low doses. siRNA assays were performed to identify the role of effe… Show more

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“…Regarding MM, the most frequently described alteration in patients is the decrease in CD4 + T lymphocyte counts, which is associated with a lower progression free survival (PFS) and overall survival (OS) and a higher relapsing probability [ 5 , 7 ]. Preliminary data from our group show higher percentages of CD4 + T cells in the BM of patients with newly diagnosed MM (NDMM) and high risk smoldering MM as compared to healthy subjects, but this was not found in patients with monoclonal gammopathy of undetermined significance (MGUS) [ 8 ]. Depending on the immunological context, CD4 + T cells can acquire phenotypes with pro or anti-inflammatory functions, named Th1 and Th2, respectively, being the balance of these two cell types important for an efficient immune response [ 9 ].…”
Section: General Alterations Of the Immune System In The Context Omentioning
confidence: 99%
“…Regarding MM, the most frequently described alteration in patients is the decrease in CD4 + T lymphocyte counts, which is associated with a lower progression free survival (PFS) and overall survival (OS) and a higher relapsing probability [ 5 , 7 ]. Preliminary data from our group show higher percentages of CD4 + T cells in the BM of patients with newly diagnosed MM (NDMM) and high risk smoldering MM as compared to healthy subjects, but this was not found in patients with monoclonal gammopathy of undetermined significance (MGUS) [ 8 ]. Depending on the immunological context, CD4 + T cells can acquire phenotypes with pro or anti-inflammatory functions, named Th1 and Th2, respectively, being the balance of these two cell types important for an efficient immune response [ 9 ].…”
Section: General Alterations Of the Immune System In The Context Omentioning
confidence: 99%