2016
DOI: 10.1017/cjn.2016.376
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PS2 - 195 Integrating Molecular Workings into the World Health Organization (WHO) Classification of Tumours of the Central Nervous System: A Survey from the Neuro-Oncology Community

Abstract: Suppl 4 -S16 brain indicating that RXFP1 signaling in GB is activated by auto-/paracrine secretion of CTRP8. In GB, RXFP1 signaling included PI3K and PKC activation and resulted in the increased production and secretion of lysosomal protease cathepsin B, a known prognostic marker of GB. In the present study, we have investigated the potential role of RXFP1 in chemoresistance to the commonly used DNA alkylating drug temozolomide (TMZ) in human GB. Upon TMZ treatment, CTRP8/RLN2 mediated activation of RXFP1 was … Show more

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