Pseudo-Cryptand-Containing Copolymers: Cyclopolymerization and Biocompatible Water-Soluble Al³⁺ Fluorescent Sensor in Vitro

Abstract

A series of novel pseudo-cryptand-containing copolymers (PDStPEG m MA) with different sizes were constructed by maleic anhydride (MAn)-assisted reversible addition−fragmentation chain transfer (RAFT) alternative cyclopolymerization of distyrenic 18-membered macrocycle derivatives. Pyrene and hydrophilic methoxypoly(ethylene glycol)s (MPEG) segments were then grafted onto the polymer backbone by amidation and esterification reactions and thus endowed polymers with fluorescent properties and water solubility, respectively. The size-dependent ion recognition property of these pseudo-cryptand-containing copolymers against metal ions was also investigated by fluorescent spectra. With the water solubility and biocompatibility, PDStPEG 2 MA 10 -g-py-g-MPEG can be effectively employed as fluorescent sensors, especially for Al 3+ detection in vitro.

Soluble–Insoluble–Soluble Transitions of Thermoresponsive Cryptand-Containing Graft Copolymers

“…The structural variation of the copolymers is illustrated in Scheme 1. The chemical composition, molar masses, and other characteristics of the copolymers have been studied, and the results 52 are listed in Table 1. We have made two series of polymers with a shorter and a longer MPEG graft with 350 and 750 Da, respectively.…”

“…bCalculation based on the total number of carboxylic acid groups of maleic acid units.cMW calculated from the M w of PDStPEG m MA 10 and the graft ratio. 52 …”

“…We have designed and synthesized well-defined linear cryptand-containing copolymers, 52 and the understanding of their properties in aqueous media would be important for their use as potential smart materials. By introducing hydrophilic methoxy poly(ethylene glycol) (MPEG) segments onto the maleic anhydride units, a variety of amphiphilic cryptand-containing graft copolymers can be obtained (as shown in Scheme 1).…”

A novel nitrogen heterocycle platform-based highly selective and sensitive fluorescence chemosensor for the detection of Al3+ and its application in cell imaging

“…Recently, the highly selective and sensitive uorescence chemsensors for detecting metal ions have attracted signicant attention. [1][2][3][4][5][6][7] This is because some relevant metal elements such as copper, zinc, mercury, chromium, and aluminium play very important roles in different organisms and the environment, which are closely related to some health and pollution problems. Thus, the monitoring of metal ions is of great signicance.…”

Polyacrylamide pseudo crown ethers via hydrogen bond-assisted cyclopolymerization

“…Cyclopolymers carry in‐chain ring cavities as sequenced monomer units to potentially afford unique physical properties and/or functions, distinct form conventional polymers with noncyclized (linear) pendants . Focusing on the inherent features, various functional cyclopolymers have been designed and synthesized by cyclopolymerization of divinyl monomers via alternating processes of intramolecular cyclization and intermolecular propagation.…”