Pseudobullous pilomatricoma: A rare variant of pilomatricoma

Abstract

Pilomatricoma (PM; calcifying epithelioma of Malherbe) is an uncommon adnexal tumour originating from the matrix of the hair follicles. Bullous appearance is a rare variant of PM, and its pathogenesis remains unclear. Here, we present a case of a 17‐year‐old girl with a pseudobullous PM on the right shoulder. Lymphatic dilatation and collagen disorder were histopathologically observed in this case, which may provide clues to elucidate the pathogenesis of pseudobullous PM.

Dermatoscopic, Ultrasound and Histopathological Findings of Bullous Pilomatricoma: A Case Report

“…It is also suggested that the inflammatory cells surrounding the pilomatricoma produce elastinolytic enzymes like Matrix Metalloproteinase (MMP) 9 and 12, which alter and destroy elastic fibers and collagen. This further facilitates the dilation of lymphatic vessels and allows the accumulation of fluid in the dermis, forming the blister [9,10].…”