Pseudocontinuous arterial spin labeling perfusion magnetic resonance imaging—A normative study of reproducibility in the human brain

Wu, Wen‐Teng; Jiang, Shu-Fen; Yang, Shi-Yi; Lien, Shu-Hua

doi:10.1016/j.neuroimage.2011.02.080

Cited by 51 publications

(51 citation statements)

References 21 publications

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“…Second, prescribing postlabel delay based on arterial blood velocity may help to distinguish aspects of arterial transit time that separate slower flow velocity from collateral or tortuous pathways. The GM-CBF values observed here are consistent with those in other studies involving younger adults, 27 healthy older adults, 28 and individuals with chronic stroke. 29 Older adults with WMH, however, exhibited lower GM-CBF than previously reported.…”

Section: Discussionsupporting

confidence: 91%

Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity

Robertson

Matta

Basile

et al. 2017

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The relationship between extracranial large-artery characteristics and arterial spin-labeling MR imaging may influence the quality of arterial spin-labeling-CBF images for older adults with and without vascular pathology. We hypothesized that extracranial arterial blood velocity can explain between-person differences in arterial spin-labeling data systematically across clinical populations.

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Section: Discussionsupporting

confidence: 91%

Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity

Robertson

Matta

Basile

et al. 2017

AJNR Am J Neuroradiol

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“…Several reports have focused on the repeatability of CBF measurement by ASL imaging. 11,14,[27][28][29][30] Interday repeatability indicates the capability of detecting alterations in CBF in the longitudinal assessment of disease status. CVR can be assessed by ASL imaging before and after ACZ injection in 1 imaging session, and intra-session repeatability is essential for this assessment.…”

Section: Discussionmentioning

confidence: 99%

Arterial Spin-Labeling Evaluation of Cerebrovascular Reactivity to Acetazolamide in Healthy Subjects

Inoue¹,

Tanaka

Hata

et al. 2013

American Journal of Neuroradiology

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“…This body coil calibration scan was used to correct the pCASL data for the uneven sensitivity profile of the 32-channel head coil. 18 A T1-weighted structural image was acquired for tissue segmentation and registration purposes. We additionally acquired a phase contrast angiography image (repetition time = 72.9 ms, echo time = 4.82 ms, field of view = 240 × 240, matrix = 128 × 128, slice thickness = 5 mm, flip angle = 15 degrees, velocity encoding = 100 cm/s) in the same position as the labeling plane to assess blood flow velocity and inversion efficiency, 28 and corresponding B0 field map images to correct for echo-planar imaging distortion effects.…”

Section: Magnetic Resonance Data Acquisitionmentioning

confidence: 99%

“…15 When compared with pulsed ASL (pASL) and CASL, pCASL is shown to be the least variable. [16][17][18] Longitudinal repeatability of pCASL has also been validated for neurodevelopmental studies in children.…”

Section: Introductionmentioning

confidence: 99%

Optimization and Reliability of Multiple Postlabeling Delay Pseudo-Continuous Arterial Spin Labeling during Rest and Stimulus-Induced Functional Task Activation

Mezue

Segerdahl

Okell

et al. 2014

J Cereb Blood Flow Metab

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Arterial spin labeling (ASL) sequences that incorporate multiple postlabeling delay (PLD) times allow estimation of when arterial blood signal arrives within a region of interest. Sequences that account for such variability may improve the reliability of ASL and therefore make the technique well suited for future clinical and experimental investigations of cerebral perfusion. This study assessed the within-and between-session reproducibility of an optimized pseudo-continuous ASL (pCASL) functional magnetic resonance imaging (FMRI) sequence that incorporates multiple postlabeling delays (multi-PLD pCASL). Healthy subjects underwent four identical scans separated by 30 minutes, 1 week, and 1 month using multi-PLD pCASL to image absolute perfusion (cerebral blood flow (CBF) and arterial arrival time (AAT)) during both rest and a visual-cued motor task. We show good test-retest reliability, with strong consistency across subjects and sessions during rest (inter-session within-subject coefficient of variation: gray matter (GM) CBF = 6.44%; GM AAT = 2.20%). We also report high sensitivity and reproducibility during the functional task, where we show robust task-related decreases in AAT corresponding with regions of increased CBF. Importantly, these results give insight into optimal PLD selection for future investigations using single-PLD ASL to image different brain regions, and highlight the necessity of multi-PLD ASL when imaging perfusion in the whole brain.

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Pseudocontinuous arterial spin labeling perfusion magnetic resonance imaging—A normative study of reproducibility in the human brain

Cited by 51 publications

References 21 publications

Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity

Temporal and Spatial Variances in Arterial Spin-Labeling Are Inversely Related to Large-Artery Blood Velocity

Arterial Spin-Labeling Evaluation of Cerebrovascular Reactivity to Acetazolamide in Healthy Subjects

Optimization and Reliability of Multiple Postlabeling Delay Pseudo-Continuous Arterial Spin Labeling during Rest and Stimulus-Induced Functional Task Activation

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