Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin

Synthetic and Structure-Activity Relationship Studies on Bioactive Natural Products

“…7). 80 (NUGC-3), cervix (HeLa-S3), and peripheral blood (HL-60) cells. They also reported that 42 induced depletion of intramolecular glutathione, which decreased cell viability.…”

Synthesis, Characterization, Anti-Inflammatory and in Vitro Antibacterial Activity of Some (±)-1-Aryl-7,8-Dichloroisochromans

“…Isochroman (3,4-dihydro-1H-benzo[c]pyran) is a common oxa-heterocycle structural motif in a variety of bioactive natural products such as 1,6,8-trihydroxy-3-heptyl-7-carboxyisochroman [1,2], an antibiotic and topoisomerase II inhibitor from the Penicillum sp., pseudodeflectusin [3], a selective human cancer cytotoxin from Aspergillus pseudodeflectus, isochromans from softwood lignin [4], and the male wing gland pheromone of bumblebee wax moth, Aphomia sociella [5]. Hydroxy-1-aryl-isochromans such as 1-phenyl-6,7-dihydroxyisochroman and 1-(3-methoxy-4-hydroxy)phenyl-6,7-dihydroxyisochroman have been identified in extra-virgin olive oil [6].…”

Biological Activities of the Alkaloid Quinazoline Extracted from Aspergillus nomius

“…Additionally, the TMC-120s were first reported as secondary metabolites of A. ustus (TC1118) isolated from rhizosphere of grass (Kohno et al, 1999a, b). TMC-120 B has been isolated from A. pseudodeflectus (Ogawa et al, 2004 andSlacka et al, 2009) and ester derivatives of the drimane N-(3-4-Dichlorophenyl) 2-Methyl, 2,3 Dihydroxypropio amide was isolated from A. fumigatus, this product induced apoptosis through increasing activation of caspase 3 and caspase 9 which lead to programmed cell death (Osman et al, 2007). Other two active compounds were isolated from the broth of A. fumigatus isolated from Brazil soil of the culture grown in the presence of pooled bacteria and were identified as 3,4-dimethoxyphenol and 1,3,5-trimethoxybenzene which has antimicrobial activity (Furtado et al, 2002).…”