Pseudodysplastic epithelial artefacts associated with oral mucosa CO2 laser excision: an assessment of margin status

Does a Pulsed Mode Offer Advantages Over a Continuous Wave Mode for Excisional Biopsies Performed Using a Carbon Dioxide Laser?

“…4,[16][17][18] The simulation of cytologic atypias in the deeper tissue layers also has been described. [25][26][27] The thermally denatured tissue also represents a barrier to healing of the wound site. A prolonged activation of inflammatory cells is the likely reason for a delay in wound healing.…”

“…In a recent animal study using a pulsed wave mode, the mean thermal damage zone was 298.7 Ϯ 150.7 m, also showing no significant difference in the width of the zone of necrosis between low (3 W) and high (6, 9, 12 W) wattages. 27 However, the pulsed CO 2 laser has been judged to decrease the thermal damage zone compared with the CW mode. One of the first studies on the effect of CO 2 laser pulse duration (2 s, 600 s, 2 ms, 50 ms) on the zone of thermal damage was conducted by Walsh et al 28 on epilated guinea pig skin, with reported depths of damage of 50, 70, 170, and 750 m, respectively.…”

How to Help the Oral Pathologist in Making an Accurate Diagnosis

“…These artefacts could be critical when the dysplastic changes are being assessed as the thermal damage which is induced along the laser treated margins would simulate a cytological atypia [10].…”

Pseudodysplastic artefacts of the oral mucosa created by the electrotome

“…In a recent study, Seoane et al [9] examined wounds of rat tongue mucosa caused by a CO 2 laser evaluating size and histological features. They found artefacts situated in basal and suprabasal epithelial layers.…”