2021
DOI: 10.1038/s41420-021-00531-y
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Pseudogene ACTBP2 increases blood–brain barrier permeability by promoting KHDRBS2 transcription through recruitment of KMT2D/WDR5 in Aβ1–42 microenvironment

Abstract: The blood–brain barrier (BBB) has a vital role in maintaining the homeostasis of the central nervous system (CNS). Changes in the structure and function of BBB can accelerate Alzheimer’s disease (AD) development. β-Amyloid (Aβ) deposition is the major pathological event of AD. We elucidated the function and possible molecular mechanisms of the effect of pseudogene ACTBP2 on the permeability of BBB in Aβ1–42 microenvironment. BBB model treated with Aβ1–42 for 48 h were used to simulate Aβ-mediated BBB dysfuncti… Show more

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Cited by 10 publications
(7 citation statements)
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“…TCF19 may act as a susceptibility gene for non-small cell carcinoma in the Chinese populations, interacting with tumor suppressor protein ( P53 ) and playing a role in various metabolic pathways, including cancer and diabetes [ 41 ]. KHDRBS2 has a regulatory role in microenvironmental permeability, hereditary retinopathy, and cancer [ 42 , 43 ]. We also identified a positive selection signal for a tumor suppressor-associated gene ( DLC1 ) on chromosome 8 [ 44 ].…”
Section: Resultsmentioning
confidence: 99%
“…TCF19 may act as a susceptibility gene for non-small cell carcinoma in the Chinese populations, interacting with tumor suppressor protein ( P53 ) and playing a role in various metabolic pathways, including cancer and diabetes [ 41 ]. KHDRBS2 has a regulatory role in microenvironmental permeability, hereditary retinopathy, and cancer [ 42 , 43 ]. We also identified a positive selection signal for a tumor suppressor-associated gene ( DLC1 ) on chromosome 8 [ 44 ].…”
Section: Resultsmentioning
confidence: 99%
“…Pseudogenes do not have protein coding capability; however, they may play a role in epigenetic regulation, gene transcription and post-transcriptional gene regulation. Pseudogenes are reported to play a role in the development and clinical manifestation of prion diseases and related neurodegenerative diseases [ 32 , 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…TF can bind to specific promoter regions of TJ-related proteins to regulate TJ-related proteins expression [ 47 , 52 ]. NFATC3 acting as a TF has been researched widely in EC biology.…”
Section: Discussionmentioning
confidence: 99%