Pseudomonas aeruginosa pili mediate binding to human corneal epithelial glycoproteins

Management of bacterial keratitis: beyond exorcism towards consideration of organism and host factors

“…19 The corneal epithelial receptors for Pseudomonas spp are glycoproteins. 20,21 Pili (fimbriae) are thin (4-10 nm in diameter) protein filaments, which are located on the surfaces of many bacteria. In vitro studies indicate that purified pili successfully compete for binding with cold bacteria by saturating available binding sites on the ocular surface.…”

“…20 Fortified topical antibiotics applied every 30 min are equally effective to administration every 15 min. 76 To achieve rapidly peak corneal concentrations, a 'loading' dose of antibiotic is initiated with frequent, repetitive administration.…”