Pseudomonas mastoiditis

Morgenstein, Karl M.; Seung, Hong Il

doi:10.1288/00005537-197102000-00003

Cited by 23 publications

(1 citation statement)

References 13 publications

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“…Malignant external otitis is a relatively recent clinical entity which has been described in detail in previous reports (Meltzer and Keleman, 1959;Chandler, 1968Chandler, , 1977. This is a severe external otitis which proceeds towards an infiltrating osteomyelitis of the skull base and may be lethal when untreated (Meltzer and Keleman, 1959;Chandler, 1968Chandler, , 1977Morgenstein and Seung, 1971;Wilson et al, 1971;Petrozzi, 1974;Nadol, 1980;Babiatzki and Sade, 1987). Today the survival rate is excellent when the basic underlying disease, such as diabetes mellitus, is adequately treated and when appropriate and prolonged antipseudomonal therapy is employed.…”

Section: Discussionmentioning

confidence: 99%

Histopathology of the soft parts in 50 patients with malignant external otitis

Bernheim¹,

Sadé

1989

J. Laryngol. Otol.

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Reports concerning the lesions of the skin coverage of the external ear canal in malignant external otitis (M.E.O.) are very few. To evaluate this problem, we studied the skin lesions of 45 skin biopsies from 40 M.E.O. patients, 23 from regions covering the osseous part of the ear structure, seven from the cartilaginous part of the external canal and 15 from both parts. The epidermis was normal in nine, thickened in 16, with acanthotic thickening and pseudoepitheliomatous hyperplasia in 20. In the dermis the amount of collagen was normal, but it was infiltrated by the inflammatory process. Acute inflammation was observed in 16 biopsies, subacute in 23, chronic in six. A mixture of acute and chronic changes was present in 18 biopsies. No major abnormalities of the vasculature could be detected. The distinguishing pathological feature of M.E.O. concerns the typical topographic distribution of the inflammation in the osseous part of the external ear canal.

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Section: Discussionmentioning

confidence: 99%

Histopathology of the soft parts in 50 patients with malignant external otitis

Bernheim¹,

Sadé

1989

J. Laryngol. Otol.

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Progressive Necrotizing External Otitis: Treatment with Ticarcillin and Tobramycin

Horwitz¹,

Templeton²

1977

The Laryngoscope

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The history of necrotizing external otitis, its diagnosis and management are reviewed. A case history is presented of a patient who was diagnosed as having progressive necrotizing external otitis with facial paralysis. In spite of standard medical treatment and aggressive surgical management, the disease process continued with progressive involvement of Cranial nerves IX and X. The Pseudomonas aeruginosa bacteria developed an increased minimal inhibitory concentration (MIC) to carbenicillin and gentamicin by requiring near toxic blood levels to be effective. Investigational ticarcillin (alpha-carboxy-3-thienylmethylpenicillin) and tobramycin were used successfully in resolving the infection.

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Far advanced malignant external otitis: Report of a survival

Aldous¹,

Shinn²

1973

The Laryngoscope

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Malignant external otitis has been the subject of several reports since it was described by Chandler in 1968. Cranial nerve involvement has been recognized as an ominous prognostic sign. Mortality has been about 50 percent (10/19) with facial nerve paralysis, and over 80 percent (9/11) with multiple cranial nerves involved. A survival of a patient with involvement of cranial nerves VII and IX‐XI is reported. Effective treatment comprised surgical debridement and Gentamicin, Carbenicillin and Colistimethate. This therapeutic regimen is presently the best available for malignant external otitis.

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Pseudomonas mastoiditis

Cited by 23 publications

References 13 publications

Histopathology of the soft parts in 50 patients with malignant external otitis

Histopathology of the soft parts in 50 patients with malignant external otitis

Progressive Necrotizing External Otitis: Treatment with Ticarcillin and Tobramycin

Far advanced malignant external otitis: Report of a survival

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