Pseudomonas putida bacteremia in pediatric patients: A case series study

Picollo, Micaela; Ferraro, Daiana; Pérez, Guadalupe; Reijtman, Vanesa; Gomez, Sandra; Garcia, Maria; Mastroianni, Alejandra; Rosanova, María Teresa

doi:10.1016/j.eimce.2022.07.007

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…D. acidovorans is generally considered a nonpathogenic environmental microorganism, however, it has been demonstrated to be linked to lung disorders and other infections in patients who are immunosuppressed or immunocompromised [56][57][58]. Similarly, P. putida, despite being mostly described as a saprophytic organism, has been known to cause opportunistic infections [59,60]. The presence of opportunistic pathogens in the nasal microbiota, especially the innately antibioticresistant S. maltophilia, could be a risk indication for an opportunistic infection for patients with chronic lower respiratory tract diseases.…”

Section: Discussionmentioning

confidence: 99%

Human nasal microbiota shifts in healthy and chronic respiratory disease conditions

Konovalovas,

Armalytė,

Klimkaitė

et al. 2024

BMC Microbiol

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Background An increasing number of studies investigate various human microbiotas and their roles in the development of diseases, maintenance of health states, and balanced signaling towards the brain. Current data demonstrate that the nasal microbiota contains a unique and highly variable array of commensal bacteria and opportunistic pathogens. However, we need to understand how to harness current knowledge, enrich nasal microbiota with beneficial microorganisms, and prevent pathogenic developments. Results In this study, we have obtained nasal, nasopharyngeal, and bronchoalveolar lavage fluid samples from healthy volunteers and patients suffering from chronic respiratory tract diseases for full-length 16 S rRNA sequencing analysis using Oxford Nanopore Technologies. Demographic and clinical data were collected simultaneously. The microbiome analysis of 97 people from Lithuania suffering from chronic inflammatory respiratory tract disease and healthy volunteers revealed that the human nasal microbiome represents the microbiome of the upper airways well. Conclusions The nasal microbiota of patients was enriched with opportunistic pathogens, which could be used as indicators of respiratory tract conditions. In addition, we observed that a healthy human nasal microbiome contained several plant- and bee-associated species, suggesting the possibility of enriching human nasal microbiota via such exposures when needed. These candidate probiotics should be investigated for their modulating effects on airway and lung epithelia, immunogenic properties, neurotransmitter content, and roles in maintaining respiratory health and nose-brain interrelationships.

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Section: Discussionmentioning

confidence: 99%

Human nasal microbiota shifts in healthy and chronic respiratory disease conditions

Konovalovas,

Armalytė,

Klimkaitė

et al. 2024

BMC Microbiol

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“…Even though the number of Pseudomonas isolates identified in blood cultures remained stable through the years, there was a statistically significant reduction of P. aeruginosa strains in the post-COVID-19 era. Infection by non- aeruginosa Pseudomonas species is relatively uncommon and it mostly occurs in patients with underlying immunocompromise, or in association with an infected medical device [ 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Pseudomonas Bacteremia in a Tertiary Hospital and Factors Associated with Mortality

et al. 2023

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Pseudomonas aeruginosa is the third most commonly identified cause among gram-negative microorganisms causing bloodstream infection (BSI) and carries a very high mortality, higher than that by other gram-negative pathogens. The aim of the present study was to assess the epidemiological and microbiological characteristics of patients with BSI by Pseudomonas spp. in a tertiary hospital, characterize the resistance rates of different Pseudomonas strains to the most clinically relevant anti-microbials, estimate the mortality rate, and identify factors independently associated with mortality. In total, 540 cultures from 419 patients sent to the microbiology department of the hospital during the 8-year period of the study were positive. Patients had a median age of 66 years, and 262 (62.5%) were male. The blood culture was drawn in the ICU in 201 of the patients (48%). The infection was hospital-acquired in 329 patients (78.5%) and the median hospital day when the blood culture was drawn was 15, with a range of 0 to 267 days. Median duration of stay in the hospital was 36 days, hospital mortality was 44.2% (185 patients), and 30-day mortality was 29.6% (124 patients). The most commonly isolated Pseudomonas species were P. aeruginosa followed by P. putida and P. oryzihabitans. There was a statistically significant reduction of P. aeruginosa isolation relative to non-aeruginosa Pseudomonas species in the post-COVID-19 era. Antimicrobial resistance of P. aeruginosa in clinically relevant antimicrobials with anti-pseudomonal activity was similar before and after the onset of the COVID-19 pandemic with the exception of gentamicin and tobramycin, with P. aeruginosa being more susceptible to these two antimicrobials in the post-COVID-19 era. Rates of multi-drug resistant (MDR), extensively-drug resistant (XDR), and difficult-to-treat (DTR) P. aeruginosa isolation were lower after the onset of the COVID-19 pandemic, even though a carbapenem-focused antimicrobial stewardship program had been implemented in the meantime. Increased age, ICU-acquisition of BSI, and more days in the hospital when positive blood culture was drawn were positively associated with 30-day mortality of patients with Pseudomonas BSI. The fact that rates of MDR, XDR, and DTR P. aeruginosa isolation were lower late in the study period, with a carbapenem-focused antimicrobial stewardship intervention being implemented in the meantime, further increases the understanding that implementation of antimicrobial stewardship interventions may halt the increase in antimicrobial resistance noted previously.

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Pseudomonas putida bacteremia in pediatric patients: A case series study

Cited by 2 publications

References 13 publications

Human nasal microbiota shifts in healthy and chronic respiratory disease conditions

Human nasal microbiota shifts in healthy and chronic respiratory disease conditions

Pseudomonas Bacteremia in a Tertiary Hospital and Factors Associated with Mortality

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