Pseudoporphyria cutanea tarda: Two case reports on children receiving peritoneal dialysis and erythropoietin therapy

Harvey, Elizabeth; Bell, C.; Paller, Amy S.; LaVoo, Elizabeth J.; Hanna, Wedad; Balfe, J. Williamson; Krafchik, Bernice R.

doi:10.1016/s0022-3476(05)81909-2

Cited by 23 publications

(5 citation statements)

References 12 publications

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“…Dermal microangiopathic changes and decreased subcutaneous oxygenation during HD might facilitate frictional blistering 73 . Other proposed factors are aluminum hydroxide 78,82 erythropoietin 83 and susceptibility to oxygen‐free radicals 84 . One study suggests that altered zinc and associated antioxidant status following dialysis leads to a partial loss of activity of 5‐aminolevulinate dehydratase and deaminase activities causing pseuodporphyria 80 …”

Section: Bullous Dermatosesmentioning

confidence: 99%

A current review of the cutaneous manifestations of renal disease

2003

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Section: Bullous Dermatosesmentioning

confidence: 99%

A current review of the cutaneous manifestations of renal disease

2003

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“…Two cases of children receiving erythropoietin and peritoneal dialysis were documented by Harvey et al [7].…”

Section: Discussionmentioning

confidence: 97%

“…Another case was of a 12-year-old child who had glomerulonephritis-related chronic renal failure. Within two weeks of starting erythropoietin, he began to develop several fluid-filled lesions across sun-exposed areas [7]. Gyldenløve et al [8] discussed the case of a 69-year-old paraplegic woman with a history of antiphospholipid syndrome and vitiligo who presented with tense bullae on both knees following sun exposure.…”

Section: Discussionmentioning

confidence: 99%

Drug-Induced Pseudoporphyria: A Case Report

Jangid,

Saoji,

Madke

et al. 2024

Cureus

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Pseudoporphyria is an uncommon dermatosis resembling porphyria cutanea tarda (PCT). The exclusion of true porphyria, especially PCT, is critically essential for diagnosing pseudoporphyria. It has an unknown underlying pathophysiology with a normal or near-normal porphyrin profile. Pseudoporphyria has been associated with chronic renal failure and hemodialysis, medications, and tanning beds. In drug-induced pseudoporphyria cases, eliminating the suspected photosensitizing drug improves the disease typically within weeks to months (on average eight weeks). In genetically predisposed individuals, phototoxic metabolites may trigger the development of skin fragility, bullae, milia, and scarring on the dorsum of the hands and other sun-exposed areas. Wearing a broad-spectrum sunscreen and maintaining strict ultraviolet protection is essential in cases of pseudoporphyria.We report the case of a 20-year-old male who presented to us with complaints of photosensitivity and multiple erosions with irregular scars over photo-exposed areas involving the dorsum of the hands and face predominantly. The patient was evaluated further to determine the underlying cause. A wood's lamp examination of the urine was done, which did not show fluorescence. Based on clinical and laboratory findings, the diagnosis of pseudoporphyria was made, and the patient was started on the oral antimalarial agent hydroxychloroquine sulfate with strict sun protection.

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“…In contrast to PCT, hypertrichosis, hyperpigmentation, and sclerodermoid skin changes are usually absent, and there is no abnormality of porphyrin metabolism. Pseudoporphyria has been described in patients undergoing hemodialysis or 179 peritoneal dialysis, 180 after intake of certain drugs 165 or after phototherapy. 181 …”

Section: Porphyriasmentioning

confidence: 99%

Cutaneous Deposits

Molina-Ruiz

Cerroni

Kutzner

et al. 2014

The American Journal of Dermatopathology

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: The cutaneous deposition disorders are a group of unrelated conditions characterized by the accumulation of either endogenous or exogenous substances within the skin. These cutaneous deposits are substances that are not normal constituents of the skin and are laid down usually in the dermis, but also in the subcutis, in a variety of different circumstances. There are 5 broad categories of cutaneous deposits. The first group includes calcium salts, bone, and cartilage. The second category includes the hyaline deposits that may be seen in the dermis in several metabolic disorders, such as amyloidosis, gout, porphyria, and lipoid proteinosis. The third category includes various pigments, heavy metals, and complex drug pigments. The fourth category, cutaneous implants, includes substances that are inserted into the skin for cosmetic purposes. The fifth category includes miscellaneous substances, such as oxalate crystals and fiberglass. In this article, the authors review the clinicopathologic characteristics of cutaneous deposition diseases, classify the different types of cutaneous deposits, and identify all the histopathologic features that may assist in diagnosing the origin of a cutaneous deposit.

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Pseudoporphyria cutanea tarda: Two case reports on children receiving peritoneal dialysis and erythropoietin therapy

Cited by 23 publications

References 12 publications

A current review of the cutaneous manifestations of renal disease

A current review of the cutaneous manifestations of renal disease

Drug-Induced Pseudoporphyria: A Case Report

Cutaneous Deposits

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