Pseudoxanthoma elasticum-like papillary dermal elastolysis in non-exposed skin

Setó-Torrent, N; Iglesias‐Sancho, Maribel; Arandes-Marcocci, Jorge; Fernández‐Figueras, María Teresa

doi:10.1016/j.abd.2019.08.024

Cited by 6 publications

(9 citation statements)

References 5 publications

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“…In early stages, a perivascular and periadnexal lymphocytic inflammatory infiltrate has been described, which may hinder the diagnosis. 2,5,8,14 In our case, the infiltrate in the superficial dermis with marked folliculotropism and a congruent immunophenotype led us to suspect the diagnosis of folliculotropic mycosis fungoides histopathologically. Clinicopathologic correlation, however, allowed us to establish the right diagnosis, and the folliculotropic infiltrate of the first biopsy was blamed on the follicular inflammation that may exist in the initial stages of PDE.…”

Section: Discussionmentioning

confidence: 62%

“…In early stages, a perivascular and periadnexal lymphocytic inflammatory infiltrate has been described, which may hinder the diagnosis 2,5,8,14 . In our case, the infiltrate in the superficial dermis with marked folliculotropism and a congruent immunophenotype led us to suspect the diagnosis of folliculotropic mycosis fungoides histopathologically.…”

Section: Discussionmentioning

confidence: 66%

“…PDE is a rare acquired disease of elastic tissue that mainly affects elderly women as small firm papules mainly located in the neck, the supraclavicular areas and the upper back. 1,3,8 Other locations, like the lower abdomen, the antecubital fossae or the axillae have been also reported. 9 Ultraviolet radiation, topical use of corticosteroids or intrinsic aging have been hypothesized as possible triggers, although the pathogenesis remains unknown.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

“…Histopathologically, no specific changes are observed with H&E stain (“invisible dermatosis”). However, specific elastic tissue stains such as Verhoeff‐van Gieson and orcein show a papillary dermis with a total or almost total loss of elastic fibers, whereas these fibers are preserved or slightly diminished in the reticular dermis 2,3,5,7,8 …”

Section: Introductionmentioning

confidence: 99%

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Papillary dermal elastolysis histopathology mimicking folliculotropic mycosis fungoides

et al. 2023

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Papillary dermal elastolysis is a rare acquired disease of the elastic tissue that mainly affects elderly women with a clinical presentation of small firm papules in the neck, the supraclavicular areas and the upper back. Histopathologically, it is characteristic to find a complete or almost complete absence of elastic fibers in the papillary dermis with stains such as orcein or Verhoeff‐Van Gieson. We present the case of an adult female patient presenting a clinical picture of years of evolution of elastic skin‐colored papules on her neck, occasionally pruritic. Two biopsies were performed. In one of them an inflammatory infiltrate affecting the hair follicles was observed, and she was diagnosed with mycosis fungoides. The other biopsy showed a total absence of elastic fibers in the papillary dermis and was diagnosed as elastolysis of the papillary dermis. In early stages of papillary dermal elastolysis, a perivascular and periadnexal lymphocytic inflammatory infiltrate has been described, as is the case described above. It is important for dermatopathologist to know this atypical but possible presentation, as it may require a differential diagnosis with other entities such as follicular mycosis fungoides.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Papillary dermal elastolysis histopathology mimicking folliculotropic mycosis fungoides

et al. 2023

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Acquired Disorders of Dermal Connective Tissue

Fahy,

Lovell

2024

Rook's Textbook of Dermatology

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This chapter reviews acquired changes in dermal connective tissue during normal ageing and in disease processes, including photodamage. Corticosteroids are a potent cause of dermal atrophy, which may also be congenital or induced by inflammatory disorders related to morphoea. Enzymatic degradation of elastic tissue results in localised or generalised skin laxity, which resembles genetic disorders such as pseudoxanthoma elasticum and cutis laxa. In contrast, some disorders are characterised by excessive deposition of collagen or elastic tissue. Fibrosis is associated with contracture, which causes deformity and restricted movement as in palmoplantar fibromatosis. Several chemical environmental triggers induce diffuse fibrosis resembling systemic sclerosis. Keloids represent an abnormal scarring response to trauma. Finally, dermal connective tissue components may be extruded via the epidermis in perforating disorders such as elastosis perforans serpiginosa.

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The Spectrum of Acquired Elastolytic Disorders

Gambichler

2021

New and Emerging Entities in Dermatology and Dermatopathology

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Pseudoxanthoma elasticum-like papillary dermal elastolysis in non-exposed skin

Cited by 6 publications

References 5 publications

Papillary dermal elastolysis histopathology mimicking folliculotropic mycosis fungoides

Papillary dermal elastolysis histopathology mimicking folliculotropic mycosis fungoides

Acquired Disorders of Dermal Connective Tissue

The Spectrum of Acquired Elastolytic Disorders

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