Psoriasin, A Multifunctional Player in Different Diseases

Abstract

Psoriasin (S100A7) is one of the members in the S100 protein family. It was first discovered as a protein abundantly expressed in psoriatic keratinocytes. Psoriasin has been implicated in a wide range of intracellular and extracellular functions, including regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, cell invasion and motility, cytoskeleton dynamics, protein phosphorylation, regulation of transcriptional factors, immune responses, chemotaxis, inflammation and pluripotency. Altered expression of psoriasin was shown to associate with a broad range of diseases, including inflammatory and immune disorders and tumors. Many lines of evidence suggested that psoriasin exerts its distinct functions through alterations in both intracellular and extracellular pathways and results alteration in gene expression. In this review, we summarize the multiple function of psoriasin and the underlying mechanisms and discuss the potential role of psoriasin as one of the biomarkers and therapeutic targets for multiple diseases.

OLFM4, LY6D and S100A7 as potent markers for distant metastasis in estrogen receptor‐positive breast carcinoma

“…LY6K was found to cause metastasis of breast cancer cells, while LY6A/E promoted breast tumorigenesis in mouse models . Finally, S100A7 (S100 calcium‐binding protein A7) is a member of the S100 family of calcium‐binding proteins and regulates various cellular functions, such as calcium homeostasis, cell proliferation, differentiation, apoptosis and cell invasion . S100A7 enhanced the growth and invasive properties of breast cancer, and it was considered to play an important role in the progression of breast cancer .…”

Salivary psoriasin (S100A7) correlates with diffusion capacity of carbon monoxide in a large cohort of systemic sclerosis patients

“…The pathogenetic relationship between psoriasin and lung impairment is still far from being completely clarified. As far as psoriasin is concerned different intracellular and extracellular functions have been suggested for this protein, including regulation of calcium homeostasis, cell proliferation, differentiation, apoptosis, cell invasion and motility, cytoskeleton dynamics, protein phosphorylation, regulation of transcriptional factors, immune responses, chemotaxis, antimicrobial, and inflammation [13]. In particular, a role of chemoattractant agents which are able to stimulate the neutrophyl and CD4 +  T lymphocyte infiltration has been hypothesized by us to explain the link between psoriasin and lung involvement [8].…”

Transcriptomic analysis of FUCA1 knock‐down in keratinocytes reveals new insights into the pathogenesis of fucosidosis skin lesions

“…Keratins form intermediate filaments, a complex dynamic cytoskeleton structure providing tissue stability, mechanical integrity and flexibility. S100A7 encodes psoriasin, a protein having multiple functions such as calcium homoeostasis regulation, cell differentiation/proliferation, apoptosis, cytoskeleton function, inflammation and immune response . Keratins (eg KRT6,‐16, ‐17) and molecules related to damage‐associated molecular patterns (S100 proteins, some chemokines and cytokines) are overexpressed secondary to keratinocytes’ stress conditions which have been linked to several diseases’ pathophysiology .…”