Psoriasis, An inflammatory condition associated with oxidative stress

Abstract

Background: Psoriasis is a chronic inflammatory skin disease characterized by pathological skin lesions due to various exogenous and endogenous factors. Oxidative stress can be one of the causes for the occurrence of psoriasis as well as significant contributor to its progression. Skin exposure to a number of irritants or proinflammatory agents including UVA and UVB generates ROS through the oxidative burst in infiltrating leukocytes at the site of inflammation which damages the skin cells. Measurement of the oxidative stress marker like lipid peroxidation product Malondialdehyde (MDA) and Nitric Oxide end products (NO2+NO3) along with the inflammatory marker hs-CRP in Psoriasis patients can uncover their role in disease causation, progression and development of various co-morbidities and timely prevention can significantly improve the quality of life of the psoriasis patients.
 Aims and Objectives: To measure the oxidative stress marker like lipid peroxidation product Malondialdehyde (MDA) and Nitric Oxide end products (NO2+NO3) along with the inflammatory marker hs-CRP in Psoriasis patients to uncover their role in disease causation, progression and development of various co-morbidities and timely prevention to significantly improve the quality of life of the psoriasis patients.
 Materials and Methods: Fifty patients of psoriasis mainly plaque type of either sex, in the age group of 35 ± 15.5 (range: 7-79) years were taken following inclusion and exclusion criteria. To evaluate the oxidative stress lipid peroxidation product malondialdehyde (MDA) and Nitric Oxide end products (NO2 + NO3) were measured. hs-CRP was measured as an inflammatory marker and their correlation with the disease severity and duration was evaluated.
 Results: A significant increase in malondialdehyde (MDA), Nitric Oxide end products (NOx) and hs-CRP levels (P<0.001) was noted in Psoriatic patients as compared to controls. There was a positive correlation between MDA, NOx and hs-CRP levels with the severity and duration of the disease. The correlation between hs-CRP and MDA and NOx also showed positive trend.
 Conclusion: Oxidative stress is one of the factors which can lead to the causation of Psoriasis and also significantly contribute to the disease progression and development of various co-morbidities. By measuring the oxidative stress marker and inflammatory marker in psoriasis patients early in the disease process we can employ preventive strategies for better management and improve the survival and quality of life.

Anti-Psoriatic Activity of Black, Green and White Tea Extracts from Southeastern China

“…Firstly, the cellular safety of all TEs used was known from the MTT results. Oxidative stress may be one of the reasons for the development of psoriasis [ 39 ]. ROS have been reported to damage cellular components and its increased production has been linked to the pathogenesis of psoriasis [ 40 ].…”

Genistein—Opportunities Related to an Interesting Molecule of Natural Origin

“…It is also suggested that the onset and perpetuation of psoriatic inflammation may be associated with oxidative stress [ 57 , 58 ]. Therefore, it seems reasonable to take into account a balanced diet rich in antioxidants as an important tool in psoriasis management [ 59 ].…”

The Relationship Between Serum Endothelin-1 and Nitric Oxide Levels and Severity of Psoriasis: A Prospective Case-Control Study

“…Çalışmada psöriyazis patogenezinde oksidatif stresin önemli rol oynadığı ve hastalıktaki inflamatuar sürecin bir göstergesi olabileceği ifade edilmiştir. 26 Çalışmamızda, ortalama NO 2 ve NO 3 düzeyleri, hasta grubunda kontrol grubuna oranla yüksek bulunmuş, ancak bu yükseklik istatistiksel olarak anlamlı bulunmamıştır. Ortalama NO 2 ve NO 3 değerleri şiddetli hastalık grubunda kontrol ve hafif gruba oranla istatistiksel olarak anlamlı derecede yüksek bulundu.…”