Psoriasis and comorbidities: links and risks

Ni, Catherine; Chiu, Melvin

doi:10.2147/ccid.s44843

Cited by 73 publications

(41 citation statements)

References 191 publications

(206 reference statements)

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“…The permanent chronic inflammatory state associated with these comorbidities may lead to an increased risk of cardiovascular morbidity and mortality [34,35,36]. Thus, severe psoriasis is associated with an elevated risk of cardiovascular disease and myocardial infarction [13]. There is evidence that patients with moderate to severe psoriasis and patients with previous systemic treatment seem to be at a higher risk of obesity and, as a consequence, of cardiovascular disease than patients with mild disease [37].…”

Section: Discussionmentioning

confidence: 99%

“…The discussion of potential reasons for our epidemiological observations should include the inflammatory process in the adipose tissue as an endocrine organ [9,10,11,12,13,14], the genetic predisposition to develop obesity together with altered lifestyle habits. It has been shown that HLA-Cw6, the most important gene susceptibility locus for psoriasis, is also associated with obesity: obese patients carrying HLA-Cw6 were 35 times more likely to develop psoriasis than HLA-Cw6-negative patients of normal weight [45].…”

Section: Discussionmentioning

confidence: 99%

“…Especially abdominal fat is an active endocrine organ [9,10,11,12,13,14]. Thus, obesity is regarded as a chronic inflammatory state and is associated with the development of metabolic comorbidity [15,16,17,18].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Obesity in Patients with Psoriasis: Results of the National Study PsoHealth3

Jacobi

Langenbruch²,

Purwins³

et al. 2015

Dermatology

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Background: Psoriasis is frequently associated with obesity which possibly contributes to reduced treatment response. Objectives: Assessment of the prevalence of obesity in patients with psoriasis in Germany 2013/2014. Patients and Methods: The frequency of overweight and obesity was assessed by the body mass index (BMI) and evaluated according to the severity of psoriasis [Psoriasis Area and Severity Index (PASI)]. Results: This national, cross-sectional survey involved 83 dermatological practices and outpatient clinics, including 1,265 patients (mean age 52 years; 43.4% female). The BMI of patients with psoriasis in 2013/2014 was found to be 28.0 and therefore was significantly higher compared to that of patients with psoriasis in 2007 with a BMI of 26.9 as well as compared to the normal population in 2013 with an overall BMI of 25.9. Conclusions: The prevalence of obesity in patients with psoriasis is higher than in the normal population. The trend towards a higher BMI in patients with psoriasis continues over time.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalence of Obesity in Patients with Psoriasis: Results of the National Study PsoHealth3

Jacobi

Langenbruch²,

Purwins³

et al. 2015

Dermatology

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“…Different environmental triggers like infection (from bacteria, fungi and viruses) [2,3], medications (lithium, antimalarials and nonsteroidal anti-inflammatory drugs) [2,4,5], obesity [6] and stress [7] initiate or worsen this complex, multifactorial syndrome in genetically prone individuals. Ps patients are at a great risk of developing a number of comorbid conditions including diabetes mellitus, hypertension, coronary heart disease, inflammatory bowel disease, lymphoma and depression [8]. In addition, disorders involving musculoskeletal structures, the eyes and the gut are also common in these patients [9,10].…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species in Psoriasis and Psoriasis Arthritis: Relevance to Human Disease

Khmaladze

Nandakumar

Holmdahl³

2015

Int Arch Allergy Immunol

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Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psoriasis arthritis (PsA). Animal models that reflect the typical Ps syndrome, including both skin and joint pathology as in Ps and PsA, are valuable tools for dissecting disease pathways leading to clinical manifestations. In this context, we developed a new acute Ps and PsA-like disease model that appears after exposure to Saccharomyces cerevisiae mannan in certain mouse strains. The disease was found to be triggered by mannan-activated macrophages, leading to the activation of a pathogenic interleukin-17 pathway involving innate lymphocytes. Interestingly, the production of reactive oxygen species protected the mice from the triggering of this pathway and ameliorated Ps and PsA development.

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“…Psoriasis is known to have a number of different comorbidities, as shown in a study by Ni and Chiu [68], such as cardiovascular disease, obesity, diabetes, hypertension, dyslipidemia, metabolic syndrome, nonalcoholic fatty liver disease, cancer, anxiety and depression, and inflammatory bowel disease. Inflammatory bowel disease was found to be at a higher prevalence in psoriasis patients compared to the general population.…”

Section: Bidirectional Inflammatory and Neurochemical Phenomenonmentioning

confidence: 99%

Major Depression and Psoriasis: A Psychodermatological Phenomenon

Tohid¹,

Aleem²,

Jackson³

2016

Skin Pharmacol Physiol

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Objective: The aim of this paper was to highlight the mechanisms involved and the relationship between depression and psoriasis. Method: A comprehensive literature search was performed in various databases, and finally 88 studies were deemed relevant. Results: A significant link was found between depression and psoriasis, primarily through immune mechanisms related but not limited to the actions of inflammatory cytokines such as tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8. Conclusion: Various neuroimmunological studies point towards the notion that depression and psoriasis are associated with each other. Melatonin has also been found to be associated with both conditions. A possibility exists that both conditions can cause each other due to the possible bidirectional relationship of psoriasis and major depression. However, if this is the case, then why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression remains a question unanswered. We believe that future studies will unmask this mystery.

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Psoriasis and comorbidities: links and risks

Cited by 73 publications

References 191 publications

Prevalence of Obesity in Patients with Psoriasis: Results of the National Study PsoHealth3

Prevalence of Obesity in Patients with Psoriasis: Results of the National Study PsoHealth3

Reactive Oxygen Species in Psoriasis and Psoriasis Arthritis: Relevance to Human Disease

Major Depression and Psoriasis: A Psychodermatological Phenomenon

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