Psoriasis and skin cancer – Is there a link?

Balda, Aayushi; Wani, Irshad; Roohi, Tamsheel Fatima; Suman,; Krishna, K.L.; Mehdi, Seema; Nadiga, Abhishek PR; Makkapati, Manasa; Baig, MD Awaise Iqbal

doi:10.1016/j.intimp.2023.110464

Cited by 17 publications

(8 citation statements)

References 98 publications

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“…The final R 1 values were 0.0400 (all data). The final wR ( F 2 ) values were 0.1109 (all data). The goodness of fit on F 2 was 1.051.…”

Section: Methodsmentioning

confidence: 96%

“…The final wR ( F 2 ) values were 0.1109 (all data). The goodness of fit on F 2 was 1.051. Flack parameter = 0.04(11).…”

Section: Methodsmentioning

confidence: 96%

“…The final R 1 values were 0.0396 ( I > 2 σ ( I )). The final wR ( F 2 ) values were 0.1105 ( I > 2 σ ( I )). The final R 1 values were 0.0400 (all data).…”

Section: Methodsmentioning

confidence: 98%

“…Psoriasis is an autoimmune chronic systemic disease and is considered to be the most common immune‐mediated disease significantly affecting the quality of life of nearly 3% of the general population worldwide which brings substantial burdens to individuals and society. [ 1‐5 ] Although the detailed pathogenesis of psoriasis is still unclear, it is generally accepted that the pathogenesis of psoriasis is stimulated by keratinocyte hyperproliferation and excessive inflammatory response. [ 6‐10 ] Previous studies have shown that multiple cytokines, such as interleukin (IL)‐17 and tumor necrosis factor‐alpha (TNF‐ α ) are involved in the pathogenesis of psoriasis vulgaris.…”

Section: Background and Originality Contentmentioning

confidence: 99%

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Polyaspers A and B, the First Ergosterol‐Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507

Hu,

Li,

Shi

et al. 2023

Chin. J. Chem.

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Comprehensive SummaryPsoriasis is a chronic immune‐mediated inflammatory skin disease and the TNF‐α is an important therapeutic target of this disease. In our continuous study of bioactive natural products from fungi, the first ergosterol‐polyether adducts, polyaspers A (1) and B (2), along with two known ergosterols, (3β,5α,6α,22E)‐5,6‐epoxy‐3‐hydroxyergosta‐8,22‐dien‐7‐one (3) and calvasterol B (4), were isolated from Aspergillus sp. TJ507. Structure elucidation was accomplished by extensive spectroscopic analysis and single‐crystal X‐ray diffraction tests. Polyaspers A and B possessing an unequalled 6/6/6/5/5/6/6/6/6 nonacyclic system, and their biosynthetic pathways were proposed to include intermolecular cyclization and Diels‐Alder reactions. Activity screen of these isolates showed that 1—3 could improve the cell viability in an actinomycin D/TNF‐α induced L929 cells death model, with the EC50 values of 49.85, 46.75 and 4.99 μmol/L, respectively, and the activity of 3 was even comparable with that of the positive control SPD304. Further bioactive investigations discovered 3 could suppress the inflammatory response simulated with TNF‐α in HaCaT cells. In an imiquimod‐induced psoriasis murine model, 3 significantly restrained the development of psoriasis symptoms and reduced the expression of IL‐17 and IL‐23, presenting an anti‐psoriatic effect. As such, those ergosterol derivatives, might serve as lead compounds for the development of novel TNF‐α inhibitory agents in the clinical treatment of psoriasis.

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“…The final R 1 values were 0.0400 (all data). The final wR ( F 2 ) values were 0.1109 (all data). The goodness of fit on F 2 was 1.051.…”

Section: Methodsmentioning

confidence: 96%

“…The final wR ( F 2 ) values were 0.1109 (all data). The goodness of fit on F 2 was 1.051. Flack parameter = 0.04(11).…”

Section: Methodsmentioning

confidence: 96%

“…The final R 1 values were 0.0396 ( I > 2 σ ( I )). The final wR ( F 2 ) values were 0.1105 ( I > 2 σ ( I )). The final R 1 values were 0.0400 (all data).…”

Section: Methodsmentioning

confidence: 98%

Section: Background and Originality Contentmentioning

confidence: 99%

See 2 more Smart Citations

Polyaspers A and B, the First Ergosterol‐Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507

Hu,

Li,

Shi

et al. 2023

Chin. J. Chem.

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show abstract

“…Psoriasis is a chronic, immune-mediated inflammatory skin disease ( 1 ). According to a study by the World Health Organization, it is a significant global health concern, affecting 125 million individuals worldwide ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan

Yang,

Liu,

et al. 2024

Mol Med Rep

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Psoriasis is a chronic inflammatory dermatological disease, and there is a lack of understanding of the genetic factors involved in psoriasis in Taiwan. To establish associations between genetic variations and psoriasis, a genome-wide association study was performed in a cohort of 2,248 individuals with psoriasis and 67,440 individuals without psoriasis. Using the ingenuity pathway analysis software, biological networks were constructed. Human leukocyte antigen (HLA) diplotypes and haplotypes were analyzed using Attribute Bagging (HIBAG)-R software and chi-square analysis. The present study aimed to assess the potential risks associated with psoriasis using a polygenic risk score (PRS) analysis. The genetic association between single nucleotide polymorphisms (SNPs) in psoriasis and various human diseases was assessed by phenome-wide association study. METAL software was used to analyze datasets from China Medical University Hospital (CMUH) and BioBank Japan (BBJ). The results of the present study revealed 8,585 SNPs with a significance threshold of P<5×10 −8 , located within 153 genes strongly associated with the psoriasis phenotype, particularly on chromosomes 5 and 6. This specific genomic region has been identified by analyzing the biological networks associated with numerous pathways, including immune responses and inflammatory signaling. HLA genotype analysis indicated a strong association between HLA-A*02:07 and HLA-C*06:02 in a Taiwanese population. Based on our PRS analysis, the risk of psoriasis associated with the SNPs identified in the present study was quantified. These SNPs are associated with various dermatological, circulatory, endocrine, metabolic, musculoskeletal, hematopoietic and infectious diseases. The meta-analysis results indicated successful replication of a study conducted on psoriasis in the BBJ. Several genetic loci are significantly associated with susceptibility to psoriasis in Taiwanese individuals. The present study contributes to our understanding of the genetic determinants that play a role in susceptibility to psoriasis. Furthermore, it provides valuable insights into the underlying etiology of psoriasis in the Taiwanese community.

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The Impact of Psoriasis Treatments on the Risk of Skin Cancer: A Narrative Review

Potestio,

Tommasino,

Lauletta

et al. 2024

Adv Ther

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Psoriasis and skin cancer – Is there a link?

Cited by 17 publications

References 98 publications

Polyaspers A and B, the First Ergosterol‐Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507

Polyaspers A and B, the First Ergosterol‐Polyether Adducts with Unprecedented 6/6/6/5/5/6/6/6/6 Nonacyclic Architecture from Aspergillus sp. TJ507

Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan

The Impact of Psoriasis Treatments on the Risk of Skin Cancer: A Narrative Review

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