Psoriasis and Stress – Psoriasis Aspect of Psychoneuroendocrinology

Zangeneh, Farideh Zafari; Fazeli, Alireza; Shooshtary, F.S.

doi:10.5772/25525

Cited by 2 publications

(1 citation statement)

References 135 publications

(113 reference statements)

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“…The CRH also shows biological effects such as regulation of adhesion molecules and cytokines [ 20 , 22 ]. Also, recently in the literature, it has been found that human mast cells were particularly rich in both CRH and the structurally related peptide urocortin [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?

Cemil¹,

Yılmazer²,

Ataş³

et al. 2017

pdia

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IntroductionLichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis.AimTo determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP.Material and methodsThirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group.ResultsThe comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients.ConclusionsOur study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.

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Section: Discussionmentioning

confidence: 99%