Psoriasis and uveitis

Köse, Büşra; Uzlu, Dilek; Erdöl, Hidayet

doi:10.1007/s10792-022-02225-5

Cited by 11 publications

(6 citation statements)

References 62 publications

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“…The pathophysiological relationship between uveitis and psoriasis has not been fully elucidated; regardless, uveitis has been frequently observed in cases of psoriasis vulgaris and PsA, especially among men [ 1 , 5 , 10 – 13 ], mainly with HLA-B27 positivity [ 14 ]. Tanaka et al [ 15 ] reported an unusual distribution of uveitis in Japanese patients, being most common in psoriasis vulgaris (7/13) than in PsA (4/13).…”

Section: Discussionmentioning

confidence: 99%

Uveitis and nail psoriasis in a patient without articular involvement: a case report

et al. 2022

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Background This study aimed to report a case of bilateral anterior non-granulomatous chronic non-infectious uveitis associated with isolated nail psoriasis without articular involvement. Case presentation A 55-year-old man with a history of open-angle glaucoma was referred to our uveitis and ocular immunology center with intraocular inflammation concordant with chronic non-infectious bilateral anterior non-granulomatous uveitis. At presentation, he had moderate inflammation in the anterior chamber bilaterally and lesions characteristic of nail psoriasis. Nail psoriasis was later confirmed by nail ultrasonography performed by a radiologist who specialized in psoriasis. Appropriate clinical and paraclinical assessments were conducted, ruling out all other possible causes of uveitis. The patient required dual systemic immunomodulatory therapy with methotrexate and adalimumab, topical anti-inflammatory drugs (steroidal and non-steroidal), and anti-glaucoma therapy to achieve satisfactory inflammatory and ocular pressure control. Discussion and conclusions This is the first report of non-infectious uveitis associated with nail compromise in a patient without other manifestations of psoriasis. Despite reports on the relationship between psoriatic disease and uveitis, there is insufficient information on clinical phenotypes associated with uveitis that could lead to later diagnosis and treatment of associated intraocular inflammation. Clinicians should be aware of all subtypes of psoriasis that increases a risk of developing uveitis in these patients.

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Section: Discussionmentioning

confidence: 99%

Uveitis and nail psoriasis in a patient without articular involvement: a case report

et al. 2022

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“…Der pathophysiologische Zusammenhang zwischen Uveitis und Psoriasis ist noch nicht vollständig aufgeklärt; unabhängig davon wurde bei Psoriasis vulgaris und PsA häufig eine Uveitis beobachtet, insbesondere bei Männern [1, 5, 10-13], hauptsächlich mit HLA-B27-Positivität [14]. Tanaka et al [15] berichteten über eine ungewöhnliche Verteilung der Uveitis bei japanischen Patienten, meistens in Verbindung mit Psoriasis vulgaris (7/13), weniger häufig mit PsA (4/13).…”

Section: Diskussion Und Schlussfolgerungunclassified

Uveitis und Nagelpsoriasis bei einem Patienten ohne Gelenkbeteiligung: ein Fallbericht

et al. 2023

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Hintergrund: Ziel dieser Studie war, über einen Fall von bilateraler anteriorer, nichtgranulomatöser, chronischer, nichtinfektiöser Uveitis assoziiert mit isolierter Nagelpsoriasis ohne Gelenkbeteiligung zu berichten. Falldarstellung: Ein 55-jähriger Mann mit Offenwinkelglaukom in der Anamnese wurde an unser Uveitis- und Augenimmunologiezentrum mit einer intraokularen Entzündung übereinstimmend mit chronischer, nichtinfektiöser, bilateraler nichtgranulomatöser Uveitis überwiesen. Bei Vorstellung hatte er bilateral eine moderate Entzündung in der Vorderkammer sowie für Nagelpsoriasis charakteristische Läsionen. Die Nagelpsoriasis wurde später durch den Nagel-Ultraschall bestätigt, der von einem auf Psoriasis spezialisierten Radiologen durchgeführt wurde. Es wurden geeignete klinische und paraklinische Untersuchungen durchgeführt, die alle anderen möglichen Ursachen der Uveitis ausschlossen. Der Patient benötigte eine duale systemische immunmodulatorische Therapie mit Methotrexat und Adalimumab, topische entzündungshemmende Medikamente (steroidale und nichtsteroidale) und eine Anti-Glaukom-Therapie, um eine zufriedenstellende Kontrolle von Entzündung und Augendruck zu erreichen. Diskussion und Schlussfolgerungen: Dies ist der erste Bericht über eine nichtinfektiöse Uveitis im Zusammenhang mit einer Nagelschädigung bei einem Patienten ohne andere Manifestationen von Psoriasis. Trotz Berichten über den Zusammenhang zwischen Psoriasis und Uveitis liegen unzureichende Informationen über klinische Phänotypen in Kombination mit Uveitis vor, die zu einer späteren Diagnose und Behandlung der assoziierten intraokularen Entzündung führen könnten. Kliniker sollten sich aller Subtypen von Psoriasis bewusst sein, die bei diesen Patienten das Risiko für die Entwicklung einer Uveitis erhöhen.

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“…2,3 Numerous ocular manifestations are also associated with psoriasis, affecting the cornea, conjunctiva, and eyelids, causing blepharitis, corneal scarring, and dry eyes, among others. 4 Treatment for psoriasis, tailored to disease severity and patient preferences, ranges from conventional options such as topical therapies, phototherapy, and systemic agents, to advanced biological therapies. 5,6 Uveitis is a significant ocular inflammatory disease that involves inflammation of the uvea, the middle layer of the eye, which consists of the iris, ciliary body, and choroid.…”

Section: Introductionmentioning

confidence: 99%

“…It has been linked to a wide range of comorbidities, including psoriatic arthritis (PsA), cardiovascular diseases, metabolic syndrome, and inflammatory bowel diseases (IBD) 2,3 . Numerous ocular manifestations are also associated with psoriasis, affecting the cornea, conjunctiva, and eyelids, causing blepharitis, corneal scarring, and dry eyes, among others 4 . Treatment for psoriasis, tailored to disease severity and patient preferences, ranges from conventional options such as topical therapies, phototherapy, and systemic agents, to advanced biological therapies 5,6 …”

Section: Introductionmentioning

confidence: 99%

Unraveling the connection: Uveitis prevalence and risk factors in psoriasis patients — a population‐based study

Patt,

Ben‐Shabat,

Sharif

et al. 2024

The Journal of Dermatology

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The association between uveitis and spondyloarthropathy (SpA)‐related conditions is well‐established. However, evidence describing the link between uveitis and psoriasis, and psoriasis without concomitant SpA‐related conditions is scarce and conflicting. This large‐scale population‐based study sought to describe the prevalence and features of uveitis among psoriasis patients in Israel as well as investigating the risk for uveitis in different subgroups of psoriasis patients compared to the general population. We conducted a retrospective study utilizing the electronic database of the Meuhedet Health Maintenance Organization. The study included all patients diagnosed with psoriasis between 2000 and 2020, each patient was matched with four controls based on age, sex, place of residence, and index date. Logistic regression models were employed to assess the association between psoriasis and uveitis while adjusting for the presence of SpA‐related conditions. A total of 61 003 psoriasis patients and 244 012 matched controls were included. The prevalence of uveitis was 1.3% versus 1.1% respectively (OR 1.12; 95% CI 1.10–1.30; p < 0.001). When adjusting to psoriasis severity, concurrent SpA, and psoriasis treatment no significant association was found. The rates of uveitis among psoriasis patients with concurrent SpA‐related conditions was 3.2% compared to 1.4% in controls without psoriasis or SpA (OR 2.38; 95% CI 2.00–2.83; p < 0.001), while in psoriasis patients without SpA, the rate of uveitis was 1.0% and was similar to controls. Although crude rates of uveitis were higher in patients with severe psoriasis compared to mild psoriasis (2.1% vs. 1.1%), after adjustment, no significant association compared to controls was found in either group. Our findings suggest that the positive association between psoriasis and uveitis is primarily mediated by the coexistence of other SpA‐related conditions. These findings imply the presence of a shared pathogenetic mechanism and set the direction for a phenotypic‐targeted screening strategy.

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Psoriasis and uveitis

Cited by 11 publications

References 62 publications

Uveitis and nail psoriasis in a patient without articular involvement: a case report

Uveitis and nail psoriasis in a patient without articular involvement: a case report

Uveitis und Nagelpsoriasis bei einem Patienten ohne Gelenkbeteiligung: ein Fallbericht

Unraveling the connection: Uveitis prevalence and risk factors in psoriasis patients — a population‐based study

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