Psoriasis Beyond Local Skin Disease

Abstract

Background: Psoriasis is a skin disease that was associated with metabolic and clinical changes which suggest that psoriasis is a systemic rather than local disease.Aim: To illustrate whether psoriasis is local or systemic disease through analysis of some biomarkers. Materials andMethod: A 256 subjects with psoriasis and 221 sex and age matched controls were included in the study. Serum total cholesterol [TC], high density lipoprotein [HDL], Malondialdehyde [MDA], triglycerides [TG], and total antioxidant capacity [TCA] were determined using commercial kits.Results: There were no significant differences between psoriasis and control groups in regards to mean age and gender distribution, however, there was a significant difference [p<0.01] in BMI. Additionally, TC, TG, LDL and NHDL were significantly higher [P<0.001] in patients with psoriasis than in controls, while HDL was significantly lower in psoriasis than in controls. MDA mean serum level was significantly higher [P<0.001] lower while TCA value was significantly [P<0.001] lower in subjects with psoriasis as compared controls. Lipid profile rates and oxidation index were significantly higher in psoriasis than in controls, while the anti-oxidation index was significantly lower in psoriasis. Conclusion:These study findings suggest that psoriasis may be a systemic disease rather than local skin disease.

Role of Interleukin-18, Tumor Necrosis Factor-α, Osteopontin, Paraoxonase and Lipoprotein (a) in Psoriasis Pathogenicity.

“…Cardiovascular atherosclerotic diseases are common in psoriasis [109][110][111]. Psoriasis is beyond a skin disease as the previous studies indicated [3,[112][113][114][115]. Thus the increase in levels of LP(a) in psoriasis is a risk factor for vascular occlusion [116].…”

“…In the past, psoriasis was thought to be localized skin disease. But recent studies indicated that psoriasis inducted as localized lesion which converted later into a systemic disease [3]. Many factors affecting the prevalence of psoriasis which include: genetic, infectious, environmental, biochemical, immunological, psychological and endocrinological factors.…”

“…Psoriasis was started as a dermatologic lesion to establish the induction phase of the disease which characterized by inflammatory and immunological responses [3,5,6,7]. Subsequently, systemic inflammation, immune responses, metabolic and neurological changes was initiated and contributed to complicated course of the disease [8][9][10][11][12][13].…”