Psoriasis: Evolving treatment for a complex disease

Villaseñor‐Park, Jennifer; Wheeler, D. M.; Grandinetti, Lisa M.

doi:10.3949/ccjm.79a.11133

Cited by 46 publications

(31 citation statements)

References 52 publications

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“…Chronic inflammatory skin diseases, such as atopic dermatitis, psoriasis and rosacea are characterized by the dysregulation of cutaneous innate immunity and an increased incidence of bacteremia (24). Dysfunction of cathelicidin LL-37, a molecule proven to play a central role in innate cutaneous immunity, is expressed in all three of these diseases (25).…”

Section: Discussionmentioning

confidence: 99%

Mycotic Pseudoaneurysm of the Femoral Artery in a Patient with Psoriasis

2012

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Mycotic aneurysms of the common femoral artery are rare and usually occur in intravenous drug abusers who use the femoral vessels for injection. We herein describe a case of mycotic aneurysm of the common femoral artery caused by methicillin-sensitive Staphylococcus aureus seeding of an atherosclerotic plaque in which the bacteria possibly originated from psoriatic skin lesions. A 67-year-old Caucasian man was admitted to the hospital after experiencing chest pain for two days. He was known to have psoriasis and coronary artery disease with a history of coronary artery bypass grafting surgery three years earlier. He was found to have methicillin-sensitive Staphylococcus aureus bacteremia and later developed a mycotic aneurysm of the femoral artery opposite to the site of catheterization access. Mycotic aneurysms are rare clinical conditions associated with significant morbidity and mortality. In patients with psoriasis, a high prevalence of Staphylococcus aureus colonization of the skin makes possible bacterial seeding of existing atherosclerotic plaques. Therefore, the risk of mycotic pseudoaneurysm formation in these patients should be considered.

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Section: Discussionmentioning

confidence: 99%

Mycotic Pseudoaneurysm of the Femoral Artery in a Patient with Psoriasis

2012

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“…There are many different hormonal phases throughout a woman's lifetime and the first symptoms of psoriasis can be seen at any time, that is, in childhood, menarche, pregnancy, during hormonal contraceptive use, and menopause [12]. The severity of psoriasis may fluctuate or be influenced by each phase and this relationship can be seen as disease frequency seems to peak during puberty, postpartum, and menopause, when hormone levels fall, while symptoms improve during pregnancy, a state when hormone levels are increased [13, 14]. Recent studies have shown that female hormones significantly affect the biological and immune changes in the skin [15].…”

Section: Introductionmentioning

confidence: 99%

Psoriasis: Female Skin Changes in Various Hormonal Stages throughout Life—Puberty, Pregnancy, and Menopause

Čeović

Mance

Mokoš

et al. 2013

BioMed Research International

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Psoriasis is one of the most prevalent immune mediated skin diseases worldwide. Despite the large prevalence in both men and women, the pathogenesis of this disease has not yet been fully clarified. Nowadays, it is believed that psoriasis is most likely a T helper Th1/Th17 induced inflammatory disease. Stressful life situations are known to cause flare-ups and psoriasis activity may be linked to stress from major life events. We know that stress greatly affects both the hormone and immune systems and that there are many different hormonal phases throughout a woman's lifetime. The severity of psoriasis may fluctuate or be influenced by each phase and this relationship can be seen as disease frequency seems to peak during puberty, postpartum, and menopause when hormone levels fall, while symptoms improve during pregnancy, a state when hormone levels are increased.

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“…При приеме препарата у 15% пациентов наблюдалось повышение уровня триглицеридов в сыворот-ке крови и у 3% -гиперхолестеринемия, причем эти изме-нения в липидном профиле исчезали сразу же после прекра-щения терапии [17]. Кроме того, лечение ЦС может ослож-няться головной болью (15% случаев), парестезиями (7%), гипертрихозом (6%) и мышечно-скелетными болями (5%) [17,34].…”

Section: общие принципы лечения псаunclassified

Current views on the pharmacotherapy of psoriatic arthritis

Тарадин¹,

Ватутин²,

Antonenko³

et al. 2015

RJTAO

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Псориатический артрит (ПсА) представляет собой хро-ническое серонегативное воспалительное заболевание сус-тавов, ассоциирующееся с кожным псориазом [1][2][3]. Диаг-ностика ПсА нередко затруднена вследствие того, что у ча-сти больных превалируют не классические признаки «ис-тинного артрита», а проявления вертебрального пораже-ния, тендинита, энтезита или дактилита. При этом, если псориатическая природа суставного процесса не диагно-стируется своевременно, то, соответственно, не предпри-нимаются адекватные мероприятия по лечению больного, что приводит к прогрессирующему поражению суставов и ранней инвалидизации.Считается, что псориазом страдает примерно от 0,3 до 4,8% населения [4,5]. Среди больных псориазом диа-пазон распространения ПcА достаточно широк: по сооб-щениям разных авторов, он варьирует от 5 до 30% [6,7]. Рандомизированный телефонный опрос 27 220 жителей США выявил, что в общей популяции встречаемость ПcА составила 0,25%, а среди больных, страдающих псориа-зом, -11% [8]. В 2009 г. в Германии проведено обследова-ние 1511 пациентов с бляшечной формой псориаза, вы-явившее наличие ПсА у 20,6% больных, при этом лишь в 3% случаев суставная патология была диагностирована впервые [9]. (methotrexate, cyclosporine, leflunomide, sulfasalazine), and also a promising group of biologicals. Particular emphasis is placed on the results of using tumor necrosis factor inhibitors (etanercept, infliximab, golimumab, certolizumab pegol, adalimumab), interleukin inhibitors (ustekinumab, brodalumab), and phosphodiesterase 4 inhibitors (apremilast).

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Psoriasis: Evolving treatment for a complex disease

Cited by 46 publications

References 52 publications

Mycotic Pseudoaneurysm of the Femoral Artery in a Patient with Psoriasis

Mycotic Pseudoaneurysm of the Femoral Artery in a Patient with Psoriasis

Psoriasis: Female Skin Changes in Various Hormonal Stages throughout Life—Puberty, Pregnancy, and Menopause

Current views on the pharmacotherapy of psoriatic arthritis

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