Psoriasis: Psychosomatic, somatopsychic, or both?

Kwon, Chase W.; Fried, Richard G.; Nousari, Yasmine; Ritchlin, Christopher T.; Tausk, Francisco

doi:10.1016/j.clindermatol.2018.08.009

Cited by 16 publications

(14 citation statements)

References 99 publications

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“…Negative self-evaluation can lead to avoidance behaviours and social isolation, with negative implications for interpersonal relationships. Due to all of this, psoriasis can have a powerful impact on the quality of life and the psychological well-being of patients 20 . Research shows a high percentage of anxiety and depressive disorders in patients with psoriasis.…”

Section: Psychological Factors Immune Function and Effects On Healthmentioning

confidence: 99%

“…Immunohistological analyses show an increased number of nerve endings that release neuropeptides in psoriatic lesions compared to lesion-free skin and skin of healthy people. One of these neuropeptides, substance P, contributes to neurogenic inflammation by regulating proinflammatory cytokines 20 . In addition, psoriatic lesions contain higher concentrations of neuropeptides that are also found in higher concentrations in the brain during stressful events 13 .…”

Section: Psychological Factors Immune Function and Effects On Healthmentioning

confidence: 99%

“…In addition, psoriatic lesions contain higher concentrations of neuropeptides that are also found in higher concentrations in the brain during stressful events 13 . The psychoneuroimmunologic perspectives is also complemented by research showing beneficial effects of psychological interventions on the course of illness 20 . Alongside psoriasis, atopic dermatitis and some other skin diseases are often associated with psychological and immune influences.…”

Section: Psychological Factors Immune Function and Effects On Healthmentioning

confidence: 99%

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Psychoneuroimmunology and skin diseases

Mihić¹,

Mihatović²,

Šitum³

2019

Rad Hrvatske akademije znanosti i umjetnosti

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Psychoneuroimmunology has emerged as a broad interdisciplinary field examining the interaction between the psychological state, the nervous system, the endocrine system, and the immune system. Psychodermatology or psychocutaneous medicine is an intersection of psychiatry, psychology and dermatology. There is a growing awareness of the connection between psychosocial stress and somatic illnesses, including dermatological diseases. Psychosomatic factors are considered significant in more than a third of people suffering from skin diseases. Communication between the psyche and the skin is a complex interaction of psychological, immunologic and endocrine factors with the skin, involving a number of neuropeptides, interleukins and immune system mediators. The skin, being the largest organ of the body, is equipped with metabolic and endocrinological capacities that facilitate homeostatic control between internal and external environments. In addition to psychosocial stress, factors relevant for a psychoneuroimmunological approach to skin diseases include nutrition, gut and skin microbiota, sleep and circadian rhythm, physical activity, and orthomolecular medicine. Knowledge of psychoneuroimmunological mechanisms and factors relevant for a holistic approach is very important for a better and broader understanding of skin diseases, and for better therapeutic outcomes for patients. Sažetak:Psihoneuroimunologija se pojavila kao široko interdisciplinarno područje koje obuhvaća povezanost psihičkog stanja, živčanog sustava, endokrinološkog sustava i imunološkog sustava. Psihodermatologija ili psihokutana medicina područje je ispreplitanja psihijatrije, psihologije i dermatologije. Sve je veći broj spoznaja koja govore o vezi psihosocijalnog stresa i somatskih bolesti, uključujući dermatološke bolesti. Psihosomatski čimbenici smatraju se značajnima u više od trećine osoba oboljelih od kožnih bolesti. Komunikacija između psihe i kože uključuje složene interakcije između psiholoških, imunoloških i endokrinoloških čimbenika sa kožnim sustavom, u čemu sudjeluje niz stvorenih neuropeptida, interleukina i posrednika imunološkog sustava. Pritom je koža, kao najveći organ tijela, opremljena metaboličkim i endokrinološkim sposobnostima koje olakšavaju homeostatsku kontrolu između unutarnjih i vanjskih okruženja. Uz psihosocijalni stresa, čimbenici važni unutar psihoneuroimunološkog pristupa kožnim bolestima uključuju prehranu, mikrobiom crijeva i kože, spavanje i cirkadijalni ritam, fizičku aktivnost i ortomolekularnu medicinu. Poznavanje psihoneuroimunoloških mehanizama i čimbenika relevantnih za holistički pristup vrlo je važno zbog boljeg razumijevanje kožnih bolesti, a ujedno i za bolji terapijski ishod u bolesnika. ključne riječi: psihoneuroimunologija, psihodermatologija, kožne bolesti, stres, psorijaza, atopijski dermatitis OPEN ACCESS

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Section: Psychological Factors Immune Function and Effects On Healthmentioning

confidence: 99%

Section: Psychological Factors Immune Function and Effects On Healthmentioning

confidence: 99%

Section: Psychological Factors Immune Function and Effects On Healthmentioning

confidence: 99%

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Psychoneuroimmunology and skin diseases

Mihić¹,

Mihatović²,

Šitum³

2019

Rad Hrvatske akademije znanosti i umjetnosti

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“…Important factors that may influence the treatment efficacy are psychophysiological disorders observed in psoriatic patients. They indicate a correlation between the intensity of skin lesions and the patient's metal condition [38,39]. Jin et al observed that in a group of psoriatic patients with depression symptoms diagnosed before the pharmacotherapy the clinical response to etanercept treatment was worse as compared with patients with undiagnosed depression.…”

Section: Of Psoriasis Treatmentmentioning

confidence: 99%

“…Istotnym czynnikiem, który może wpływać na skuteczność leczenia, są zaburzenia psychofizjologiczne obserwowane u pacjentów z łuszczycą. Wskazuje się na współzależność pomiędzy nasileniem zmian skórnych a stanem psychicznym pacjenta [38,39]. Jin i wsp.…”

Section: Of Psoriasis Treatmentunclassified

An analysis of selected factors influencing the efficacy of psoriasis therapy

Grabarek¹,

Krzaczyński²,

Strzałka‐Mrozik³

et al. 2019

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Psoriasis is a chronic disease characterized by a complex immunopathogenesis of recurrent inflammation of the skin. The course and intensity of the disease depend on many genetic, environmental and behavioural factors. The treatment of psoriasis includes a therapy with ultraviolet radiation, methotrexate, cyclosporine A, keratolytic preparations, tar, anthralin, glucocorticoids, calcineurin inhibitors, retinoids, and vitamin D 3 derivatives. A new class of biological drugs (personalized therapy) that was introduced includes cytokine inhibitors, i.e. TNF-etanercept, adalimumab, infliximab, certolizumab pegol, golimumab; IL-12/23ustekinumab; IL-17-secukinumab, ixekizumab, brodalumab. Effective treatment of psoriasis is a challenge. It is an important matter in anticytokine therapy to determine the influence of factors such as age, sex, environmental factors, viral and bacterial infections, an occurrence of comorbidities, individual rate of drug metabolism, and pharmacologic interactions of additionally taken drugs. The influence of many different factors translates into obtaining a heterogeneous adequate response to molecularly targeted treatments. StreSzczenie Łuszczyca jest przewlekłą, nawracającą chorobą zapalną skóry, charakteryzującą się złożoną immunopatogenezą. Przebieg i nasilenie choroby zależą m.in. od czynników genetycznych, środowiskowych i behawioralnych. Łuszczyca istotnie wpływa na komfort i jakość życia pacjenta. Terapia opiera się na różnych strategiach, takich jak leczenie promieniowaniem ultrafioletowym, metotreksatem, cyklosporyną A, preparatami keratolitycznymi, dziegciem, antraliną, glikokortykosteroidami, inhibitorami kalcyneuryny, retinoidami i pochodnymi witaminy D 3. Do nowej klasy leków biologicznych (terapia spersonalizowana) zalicza się inhibitory TNF-etanercept, adalimumab, infliksymab, certolizumab pegol, golimumab; IL-12/23-ustekinumab; IL-17-seku

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Chemerin activity in selected pathological states of human body – A systematic review

Acewicz

Kasacka

2021

Advances in Medical Sciences

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Psoriasis: Psychosomatic, somatopsychic, or both?

Cited by 16 publications

References 99 publications

Psychoneuroimmunology and skin diseases

Psychoneuroimmunology and skin diseases

An analysis of selected factors influencing the efficacy of psoriasis therapy

Chemerin activity in selected pathological states of human body – A systematic review

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