Psoriasis therapy: problems and prospects

Abstract

Annotation. Modern therapy of psoriasis is to contain the manifestations of the disease, the choice of treatment tactics depends on the severity of the course. However, the effectiveness of standardized complex therapy remains rather low and the results of treatment are unpredictable, which requires further study of ways to increase the effectiveness of psoriasis therapy. Aim – to evaluate the effectiveness of standard psoriasis therapy. An analysis of the effectiveness of standard therapy for psoriasis was carried out in 30 patients who were under the supervision of a dermatologist at the Vinnitsa Regional Clinical Dermato-Venereal Dispensary in 2019–2020. In addition to general clinical research methods, the patients were evaluated for the skin lesion index and the severity of the psoriatic process (PASI) and the quality of life was assessed – the dermatological index of quality of life (DLQI). Statistical processing of the study data was performed using the program Statistica® (StatSoft, Tulsa Oklahoma), using the Wilcoxon test, the difference between the mean m at p<0.05 was considered probable. The results obtained showed the existence of an empirical approach to therapy and the choice of topical and systemic drugs. The low efficiency of the used therapy tactics was also found, as indicated by the insignificant dynamics of the PASI and DLQI indicators. The PASI indicator decreased from 11.6 to 7.6 (p≥0.05), and the DLQI indicator decreased from 14 to 10 points (p≥0.05). In general, the indicators of the group corresponded to the average severity of the course of the disease when it is necessary to give preference to complex topical therapy with the addition of systemic drugs in some cases. However, the question of a rational combination of drugs that can enhance the basic therapy remains open. Thus, modern therapy of patients with psoriasis is insufficiently effective in controlling both the disease itself and in relation to the impact on the quality of life of patients. Insufficient effectiveness of existing treatment combinations requires further search for promising drugs.