The paper evaluates the effect of various vitamin preparations on the morphobiochemical composition of blood and the dynamics of body weight gain in calves. For this purpose, the first group of young animals (n=10) was injected once every 14 days four times intramuscularly with the vitamin complex "Oligovit", the second group (n=10) with 4 ml of the drug "Aquiton" in a similar mode, the third – "Asidivit" with 6 ml, the fourth group of animals was a control (without treatments). It was found that calves treated with oligovit had a decrease in the activity of alkaline phosphatase (by 27.9%; P<0.05), concentrations of inorganic phosphorus (by 14.7%; P><0.05), erythrocytes (by 27.4%; P><0.01) and hematocrit (by 26.8%; P><0.05), with an increase in the hemoglobin content in erythrocytes (by 35.2%; P><0.01). Treatment of young animals with aquiton was accompanied by a decrease in phosphorus concentration (by 25.3%; P><0.001), iron level (by 75.5%; P><0.05), hematocrit (by 23.7%; P><0.05), an increase in the calcium-phosphorus coefficient (by 22.0%; P><0.001) and the concentration of hemoglobin in the erythrocyte (29.7%; P><0.01). Treatment with asidivit contributed to a decrease in the average volume of red blood cells (by 5.8%; P><0.05) and an increase in the average concentration of hemoglobin in the>˂0.05), concentrations of inorganic phosphorus (by 14.7%; P˂0.05), erythrocytes (by 27.4%; P˂0.01) and hematocrit (by 26.8%; P˂0.05), with an increase in the hemoglobin content in erythrocytes (by 35.2%; P˂0.01). Treatment of young animals with aquiton was accompanied by a decrease in phosphorus concentration (by 25.3%; P˂0.001), iron level (by 75.5%; P˂0.05), hematocrit (by 23.7%; P˂0.05), an increase in the calcium-phosphorus coefficient (by 22.0%; P˂0.001) and the concentration of hemoglobin in the erythrocyte (29.7%; P˂0.01). Treatment with asidivit contributed to a decrease in the average volume of red blood cells (by 5.8%; P˂0.05) and an increase in the average concentration of hemoglobin in the erythrocyte (by 19.3%; P˂0.05). In the control group of animals, there was an increase in globulins (by 32.0%; P˂0.05), an increase in the concentration of hemoglobin in the erythrocyte (by 21.8%; P˂0.05), with a decrease in the level of iron in the blood serum (by 62.9%; P˂0.05). The largest weight gain was obtained in calves treated with oligovite (226.0±29.0), and the smallest in the control group of animals (171.4±27.5).