PSY17 The Prevalence and Clinical Profile of Atopic Dermatitis (AD) in England: A Population Based Linked Cohort Study Using Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES)

Ameen, Muhammad; Rabe, Adrian; Blanthorn-Hazell, Sophee; Millward, Rod N.

doi:10.1016/j.jval.2020.08.2025

Cited by 4 publications

(12 citation statements)

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“…Based on the criteria used in our study, less than 1 in 10 of the adult AD population had moderate‐to‐severe disease. This is similar to a prevalence of 2.5% (95% confidence interval, 2.2%–2.8%) 5 in a UK study based on self‐reported AD and to a period prevalence 2008–2018 of 2.0% within the same UK primary care population 3 . As noted by others, 6 the true UK population prevalence may be underestimated in the CPRD as mild AD may not be captured by physicians and over‐the counter drugs are not included in medical records.…”

Section: Discussionsupporting

confidence: 83%

“…asthma, depression, anxiety and conjunctivitis) were less frequent in our study than in others. A descriptive population‐based database analysis conducted using CPRD and Hospital Episode Statistics‐linked data between 2008 and 2018 revealed depression and conjunctivitis in 22.7% and 22.4% of patients, respectively 3 . Similarly, another retrospective CPRD database analysis of patients with AD (median follow‐up 5.1 years), reported anxiety in 16.8% and depression in 24.6% 18 .…”

Section: Discussionmentioning

confidence: 99%

“…Atopic dermatitis (AD) is a common, chronic, inflammatory skin disease, characterised by pruritus and varying, relapsing skin manifestations, leading to disturbed sleep and reduced health‐related quality of life 1 . AD is often associated with comorbidities, including asthma, conjunctivitis, depression and anxiety 2,3 . The prevalence of AD in adults varies according to severity, assessment method and geographical region 1,3–5 .…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and treatment patterns of adult atopic dermatitis in the UK Clinical Practice Research Datalink

Kleyn

McKenzie

Meeks

et al. 2023

Skin Health and Disease

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The prevalence of active atopic dermatitis (AD) in adults in the UK according to disease severity shows variability. This study evaluated disease prevalence and treatment patterns among the adult UK population with AD. Data were obtained from the Clinical Practice Research Datalink (CPRD) database. Adults with active AD were identified by an AD‐related prescription or general practitioner visit within the same calendar year. Prevalence was defined as the number of patients with active AD on 1 January of each year as a percentage of the number of adults in the CPRD population on that date. Moderate‐to‐severe disease was classified as either referral to a specialist or prescription(s) for topical calcineurin inhibitors, phototherapy, or systemic treatment. Patient characteristics and treatment and referral patterns were analysed for patients with active AD in 2019. The overall prevalence of AD was stable at 2.4% per year during the period 2015–2019. In 2019, mean patient age (± standard deviation) was 52.6 ± 21.0 years, 58.2% of patients were female and mean disease duration was 9.4 ± 5.9 years. The most prescribed treatment was topical corticosteroids, in 78.5% of patients. 36.7% of patients with moderate‐to‐severe AD were prescribed systemic agents and 59.8% (vs. 32.3% of patients with mild AD) were referred to any secondary care or specialist treatment. The prevalence of active AD in the adult UK population was stable over the 5‐year period (2015–2019) and was comparable to estimates from similar studies based on UK primary healthcare records.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and treatment patterns of adult atopic dermatitis in the UK Clinical Practice Research Datalink

Kleyn

McKenzie

Meeks

et al. 2023

Skin Health and Disease

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“…Itching was the most commonly mentioned clinical impact due to AD. Based on the aggregated data points, the itching or pruritis prevalence in patients with AD ranged from 21% up to 100% [30][31][32][33][34][35].…”

Section: Clinical Burdenmentioning

confidence: 99%

“…Eleven studies reported diagnosis of depression prevalence values among patients with AD [26,30,[50][51][52][53][54][55][56][57][58]. The average of all prevalence values was 18%.…”

Section: Clinical Burdenmentioning

confidence: 99%

Burden of Atopic Dermatitis in Adults and Adolescents: a Systematic Literature Review

Fasseeh

Elezbawy²,

Korra³

et al. 2022

Dermatol Ther (Heidelb)

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Introduction: Although previously regarded as a children's disease, it is clear that atopic dermatitis (AD) is also highly prevalent in adults. Because AD is not associated with mortality, it is usually neglected compared with other, fatal diseases. However, several studies have highlighted that AD burden is significant due to its substantial humanistic burden and psychosocial effects. This study aims to summarize and quantify the clinical, economic, and humanistic burden of AD in adults and adolescents. Methods: A systematic literature search was performed in PubMed, Scopus, Cochrane, Centre for Reviews and Dissemination (CRD),

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Epidemiology of mental health comorbidity in patients with atopic dermatitis: An analysis of global trends from 1998 to 2022

Cai,

Wang,

Wang

et al. 2023

Acad Dermatol Venereol

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The prevalence rates of attention deficit hyperactivity disorder (ADHD), depression, anxiety and suicide are increasing in patients with atopic dermatitis (AD), although no research has systematically examined these trends yet. Here, we explore the prevalence of the occurrence of comorbidities, such as ADHD, depression, anxiety and suicide with AD. We searched seven electronic databases from inception to October 2022 to identify relevant studies, and the Agency for Healthcare Research and Quality (AHRQ) and Newcastle–Ottawa Scale (NOS) tools were used to assess the quality of observational studies. Statistical analysis was performed using R software. Publication bias was evaluated using Egger's and Begg's linear tests. The global prevalence rates of ADHD, depression, anxiety and suicidal ideation in patients with AD were 7%, 17%, 21% and 13%, respectively, between 1998 and October 2022. Among children (aged <18 years), North American children with AD had the highest prevalence rates of ADHD (10%), depression (13%) and anxiety (20%). Among the adult (aged ≥18 years) population, patients with AD in Africa had the highest prevalence rates of depression (36%) and anxiety (44%), while Asian adults with AD had the highest prevalence rates of ADHD (7%) and suicidal ideation (20%). These results highlight the high prevalence and comorbidity rates of mental illnesses with AD, which should be brought to the attention of patients with AD and their physicians.

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PSY17 The Prevalence and Clinical Profile of Atopic Dermatitis (AD) in England: A Population Based Linked Cohort Study Using Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES)

Cited by 4 publications

References 0 publications

Prevalence and treatment patterns of adult atopic dermatitis in the UK Clinical Practice Research Datalink

Prevalence and treatment patterns of adult atopic dermatitis in the UK Clinical Practice Research Datalink

Burden of Atopic Dermatitis in Adults and Adolescents: a Systematic Literature Review

Epidemiology of mental health comorbidity in patients with atopic dermatitis: An analysis of global trends from 1998 to 2022

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