Introduction: The most common causes of congenital abnormalities reported in newborns is duodenal obstruction. There are several conditions which may lead to worsen the patient’s prognosis are prematurity, type of obstruction and the type of surgery performed. The major objective of the present study was to summarise our clinical experience with 34 infants with duodenal atresia who underwent surgical procedures over the past 20 years. Materials and Methodology: Of the total of 96 patients, those who were reported with the diagnosis of duodenal atresia were included in the study. And this group comprised of 34 patients. The group was compared in terms of sex, birth weight, age at the time of the operation and morbidity rates. All patients were assessed by neonatal and other relevant specialists when observed to be presented with additional anomalies. Data were analysed using SPSS software (ver. 15.0; SPSS Inc., Chicago, IL, USA). Results: Of the 34 patients, 22 were males and 12 females, with a mean birth weight of 2.282.92 ± 592.98 (range, 1,180-3,400) g. The average age at the time of the operation was 6.98 ± 5.09 (range, 1-38) days.