Psychiatric comorbidity in medication overuse headache patients with pre‐existing headache type of episodic tension‐type headache

Atasoy, H. Tuğrul; Atasoy, Nuray; Ünal, Aysun; Emre, Ufuk; Sümer, Murat

doi:10.1016/j.ejpain.2004.07.006

Cited by 70 publications

(58 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This pattern of hemispheric dominance is also depicted in patients with Parkinson's disease and pathological gambling, by perfusion single-photon emission computed tomography [47]. Further, the obsessive-compulsive trait represents a major risk of headache chronification and drug dependence [48,49]. These findings thus support the leftward line bisection errors found in MOH, since some MOH patients present both medication overuse and obsessive-compulsive behaviors in clinics [50,51].…”

Section: Discussionsupporting

confidence: 75%

Line bisection in medication-overuse and chronic tension-type headaches

Zhang

Gao

Fan

et al. 2014

Translational Neuroscience

View full text Add to dashboard Cite

Background: Both medication-overuse headache (MOH) and drug dependence share similar clinical features and the latter displays some deficits in visuospatial attention. The line bisection performance might help to indicate whether there is also a disruption in the visuospatial attention in MOH. Methods: We administered the line bisection test and measured anxiety and depression levels in 21 patients with MOH, 26 patients with chronic tension-type headaches (CTTH) and in 22 healthy volunteers. Results: On average, MOH patients significantly bisected leftward when referring to both frequency and magnitude, whereas the healthy volunteers and CTTH patients bisected slightly rightward. The levels of anxiety and depression were elevated in both MOH and CTTH patients compared to healthy volunteers, but the anxiety / depression levels were not correlated with the line bisection errors in all participants. Conclusions: We found a pronounced pseudoneglect in MOH, which might indicate a relatively hyperactive right or hypoactive left hemisphere, or both, suggesting the disorder's neuropsychological mechanism might overlap with that of drug dependence.

show abstract

Section: Discussionsupporting

confidence: 75%

Line bisection in medication-overuse and chronic tension-type headaches

Zhang

Gao

Fan

et al. 2014

Translational Neuroscience

View full text Add to dashboard Cite

show abstract

“…This study was designed in agreement with the recent EFNS guidelines for the treatment of MOH (Evers and Jensen, 2011). Our study confirms previous observations about the occurrence of psychopathological disturbances in chronic headache patients with MOH (Radat et al, 2005;Atasoy et al, 2005;Sances et al, 2010;Galli et al, 2011). However, we did not find that VPA had a significant effect on psychopathological comorbidity, suggesting that its anti-migraine action is independent from its potential impact on the underlying psychopathology.…”

Section: Vpa Nsupporting

confidence: 79%

Sodium valproate in migraine without aura and medication overuse headache: A randomized controlled trial

Sarchielli

Messina

Cupini

et al. 2014

European Neuropsychopharmacology

View full text Add to dashboard Cite

Objective: To assess the efficacy, safety and tolerability of sodium valproate (800 mg/die) compared with placebo in medication-overuse headache patients with a history of migraine without aura.Methods: This is a multicenter, randomized, double-blind, placebo-controlled study enrolled medication-overuse headache patients for a 3-month treatment period with sodium valproate (800 mg/day) or placebo after a 6 day outpatient detoxification regimen, followed by a 3-month follow-up. Primary outcome was defined by the proportion of patients achieving Z50% reduction in the number of days with headache per month (responders) from the baseline to the last 4 weeks of the 3-month treatment. Multivariate logistic regression models were used on the primary endpoint, adjusting for age, sex, disease duration, comorbidity and surgery. The last-observation-carried-forward method was used to adjust for missing values.Results: Nine sites enrolled 130 patients and, after a 6-day detoxification phase, randomized 88 eligible patients. The 3-month responder rate was higher in the sodium valproate (45.0%) than in the placebo arm (23.8%) with an absolute difference of about 20% (p=0.0431). Sodium valproate had safety and tolerability profiles comparable to placebo. Conclusions:The present study supports the efficacy and safety of sodium valproate in the treatment of medication overuse headache with history of migraine after detoxification.

show abstract

“…Psychiatric complications are frequently seen in MOH patients (9). However, research of the possible mechanisms underlying these associations remains limited.…”

Section: Term "Chronic Daily Headache" (Cdh) Describes a Variety Of Hmentioning

confidence: 99%

Characteristics of Mood Disorders in Japanese Patients with Medication-Overuse Headache

Kaji

Hirata

2009

Intern. Med.

View full text Add to dashboard Cite

show abstract

Psychiatric comorbidity in medication overuse headache patients with pre‐existing headache type of episodic tension‐type headache

Abstract: Psychiatric comorbidity in MOH patients with pre-existing ETTH is common as in those with pre-existing migraine headache and MOH with regard to developing psychiatric disorders should be interpreted as a risk factor in chronic daily headache patients.

Cited by 70 publications

References 43 publications

Line bisection in medication-overuse and chronic tension-type headaches

Line bisection in medication-overuse and chronic tension-type headaches

Sodium valproate in migraine without aura and medication overuse headache: A randomized controlled trial

Characteristics of Mood Disorders in Japanese Patients with Medication-Overuse Headache

Contact Info

Product

Resources

About