Psychoactive Drugs in Mania

Shopsin, Baron; Gershon, Samuel; Thompson, Hyacinth; Collins, Patrick J.

doi:10.1001/archpsyc.1975.01760190036004

Cited by 147 publications

(21 citation statements)

References 12 publications

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“…In contrast, the comparison of haloperidol and lithium suggested that haloperidol had a stronger and more rapid effect, especially on behavior and motor activity but without sedation, while lithium acted more evenly and comprehensively on the entire range of manic symptomatology (Shopsin et al, 1975; Garfinkel et al, 1980). …”

Section: Efficacy Datamentioning

confidence: 88%

“…In severely psychotic patients, it seems inferior to haloperidol (Shopsin et al, 1975; Garfinkel et al, 1980). Overall, lithium has a wider antimanic effect than valproate and carbamazepine but a weaker effect on psychotic symptoms and a slower onset of action in comparison with antipsychotics.…”

Section: Efficacy Datamentioning

confidence: 95%

“…The earlier studies on antipsychotics supported the efficacy of chlorpromazine (Klein, 1967) and suggested that antipsychotics acted more rapidly, although lithium was more globally effective (Shopsin et al, 1975). …”

Section: Efficacy Datamentioning

confidence: 99%

“…The comparison of lithium to chlorpromazine suggested that although chlorpromazine acts faster and might be more efficacious in more agitated patients, this might be due to sedation alone, while lithium has again a broader effect on the core manic symptomatology (Platman, 1970; Prien et al, 1972; Shopsin et al, 1975). In contrast, the comparison of haloperidol and lithium suggested that haloperidol had a stronger and more rapid effect, especially on behavior and motor activity but without sedation, while lithium acted more evenly and comprehensively on the entire range of manic symptomatology (Shopsin et al, 1975; Garfinkel et al, 1980).…”

Section: Efficacy Datamentioning

confidence: 99%

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The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm

Fountoulakis

Yatham

Grunze

et al. 2016

IJNPPY

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Background:The current paper includes a systematic search of the literature, a detailed presentation of the results, and a grading of treatment options in terms of efficacy and tolerability/safety.Material and Methods:The PRISMA method was used in the literature search with the combination of the words ‘bipolar,’ ‘manic,’ ‘mania,’ ‘manic depression,’ and ‘manic depressive’ with ‘randomized,’ and ‘algorithms’ with ‘mania,’ ‘manic,’ ‘bipolar,’ ‘manic-depressive,’ or ‘manic depression.’ Relevant web pages and review articles were also reviewed.Results:The current report is based on the analysis of 57 guideline papers and 531 published papers related to RCTs, reviews, posthoc, or meta-analysis papers to March 25, 2016. The specific treatment options for acute mania, mixed episodes, acute bipolar depression, maintenance phase, psychotic and mixed features, anxiety, and rapid cycling were evaluated with regards to efficacy. Existing treatment guidelines were also reviewed. Finally, Tables reflecting efficacy and recommendation levels were created that led to the development of a precise algorithm that still has to prove its feasibility in everyday clinical practice.Conclusions:A systematic literature search was conducted on the pharmacological treatment of bipolar disorder to identify all relevant random controlled trials pertaining to all aspects of bipolar disorder and graded the data according to a predetermined method to develop a precise treatment algorithm for management of various phases of bipolar disorder. It is important to note that the some of the recommendations in the treatment algorithm were based on the secondary outcome data from posthoc analyses.

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Section: Efficacy Datamentioning

confidence: 88%

Section: Efficacy Datamentioning

confidence: 95%

Section: Efficacy Datamentioning

confidence: 99%

Section: Efficacy Datamentioning

confidence: 99%

See 2 more Smart Citations

The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm

Fountoulakis

Yatham

Grunze

et al. 2016

IJNPPY

View full text Add to dashboard Cite

show abstract

“…If the criterion is relaxed to include also active control trials, carbamazepine and clonazepam are included, and the evidence for verapamil is strengthened somewhat. Note also that chlorpromazine, the comparator for lithium in early trials, is also included by virtue of its being equal to lithium and better than baseline in five trials summarized in Table 2 (35,(37)(38)(39)41), although it is inferior to lithium but still better than baseline in two trials (36,40). Haloperidol is also included by virtue of one placebo-controlled trial (55) and one active control trial (41).…”

Section: Candidate Mood Stabilizers According To the "Two-by-two" Defmentioning

confidence: 99%