Psychological Approaches in the Treatment of Chronic Pain Patients—When Pills, Scalpels, and Needles are Not Enough

Turk, Dennis C.; Swanson, Kimberly; Tunks, Eldon

doi:10.1177/070674370805300402

Cited by 252 publications

(145 citation statements)

References 72 publications

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“…In fact, we have shown that Der p 5 can induce in rabbits IgG antibodies which strongly inhibit house dust mite-allergic patients’ IgE reactivity to Der p 5. Studies performed with recombinant allergens indicate that the induction of blocking IgG antibodies is an important mechanism in allergen-specific immunotherapy with recombinant allergens [32, 33]. It may therefore be expected that vaccination of house dust mite-allergic patients with rDer p 5 will also induce a robust Der p 5-specific and protective IgG response.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Folded Recombinant Der p 5, a Potential Diagnostic Marker Allergen for House Dust Mite Allergy

Weghofer¹,

Grote

Dall’Antonia

et al. 2008

Int Arch Allergy Immunol

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Background: Der p 5 was reported as an important allergen in Dermatophagoides pteronyssinus, which is particularly recognized by patients suffering from asthma. The aim of this study was to produce, by recombinant DNA technology, a folded Der p 5 allergen for diagnostic, therapeutic and preventive purposes. Methods: Der p 5-encoding cDNA was isolated from a λgt11 D. pteronyssinus expression cDNA library and expressed in Escherichia coli. rDer p 5 was purified to homogeneity and characterized by mass spectroscopy and circular dichroism. IgE reactivity was tested with sera from 117 mite-allergic patients and in a basophil histamine release experiment. Der p 5-specific rabbit IgG antibodies were produced for the ultrastructural localization of the allergen in mites by immunogold electron microscopy as well as for cross-reactivity studies. Results: rDer p 5 is a heat-stable protein with predominantly α-helical secondary structure which reacted with IgE from 31% of mite-allergic patients’ sera and showed no relevant cross-reactivity to group 5 allergens from storage mites and tropical mites. rDer p 5-specific rabbit IgG antibodies inhibited mite-allergic patients’ IgE binding to Der p 5 and allowed to localize the allergen in secretory granules of midgut epithelial cells of house dust mites. Conclusions: The described rDer p 5 molecule may be useful for diagnosis and immunotherapy of house dust mite-allergic patients.

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Section: Discussionmentioning

confidence: 99%

Characterization of Folded Recombinant Der p 5, a Potential Diagnostic Marker Allergen for House Dust Mite Allergy

Weghofer¹,

Grote

Dall’Antonia

et al. 2008

Int Arch Allergy Immunol

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“…Areas that have been extensively explored are cardiovascular [120,161,162,163,164,165], gastrointestinal [166], pulmonary [167], neurological disorders [168], chronic pain [169,170], diabetes [171,172], HIV/AIDS [173,174], and cancer [175,176,177]. These interventions may improve lifestyle and self-management, coping, quality of life, distress (especially depression and anxiety), course of physical illness, treatment adherence, and reduction in utilization of medical services [157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177]. Dealing with the psychological distress of family caregivers is another important area of action [178].…”

Section: Integration Of Psychological Care Into Medical Treatmentmentioning

confidence: 99%

Current Psychosomatic Practice

Fava

Cosci²,

Sonino³

2016

Psychother Psychosom

254

317

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Psychosomatic research has advanced over the past decades in dealing with complex biopsychosocial phenomena and may provide new effective modalities of patient care. Among psychosocial variables affecting individual vulnerability, course, and outcome of any medical disease, the role of chronic stress (allostatic load/overload) has emerged as a crucial factor. Assessment strategies include the Diagnostic Criteria for Psychosomatic Research. They are presented here in an updated version based on insights derived from studies carried out so far and encompass allostatic overload, type A behavior, alexithymia, the spectrum of maladaptive illness behavior, demoralization, irritable mood, and somatic symptoms secondary to a psychiatric disorder. Macroanalysis is a helpful tool for identifying the relationships between biological and psychosocial variables and the individual targets for medical intervention. The personalized and holistic approach to the patient includes integration of medical and psychological therapies in all phases of illness. In this respect, the development of a new psychotherapeutic modality, Well-Being Therapy, seems to be promising. The growth of subspecialties, such as psychooncology and psychodermatology, drives towards the multidisciplinary organization of health care to overcome artificial boundaries. There have been major transformations in health care needs in the past decades. From psychosomatic medicine, a land of innovative hypotheses and trends, many indications for changes in the current practice of medicine are now at hand. The aim of this critical review is to outline current and potential clinical applications of psychosomatic methods.

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“…Diseases diagnosed in the prescription are shown in Fig. 3 [2][3][4] An analgesic (commonly known as painkiller) is a member of the diverse group of drugs used to relieve pain. Analgesic drugs act in a variety of ways on the peripheral and central nervous systems; they include paracetamol, NSAIDs such as diclofenac, narcotic drugs such as morphine, synthetic drugs having narcotic properties such as tramadol, and others.…”

Section: Resultsmentioning

confidence: 99%

Prescription of analgesics in orthopaedic outpatient department at a tertiary health care facility

2017

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The objective of the present prospective cross sectional descriptive study was to evaluate the prescribing pattern of analgesic drug by orthopaedic surgeons in outdoor patients. This study was conducted in the orthopaedic outpatient department (OPD) of the Department of Orthopaedics, Border Guard Hospital, Pilkhana, Dhaka for six months period from January 2016 to June 2016. Randomly selected 324 prescriptions were collected from the attending patients on OPD and analyzed. The details of prescribed drugs, various analgesics, monotherapy or combined therapy and use of generic name were analyzed. Among the 324 study prescriptions, males and females were 63.9% and 36.1%, respectively. Majority of patients (80.8%) were within 31-60 years of age. Different classes of drugs were prescribed: non-selective non-steroidal anti-inflammatory drugs (NSAIDs) use was 45.2%, selective NSAIDs 2.9%, opioid analgesics 7.3%, H2 blockers 13.6%, proton pump inhibitors 17.1%, muscle relaxants 4.0%, benzodiazepines 8.1%, and other adjuvants 1.9%. Among individual analgesics: diclofenac 23.5%, aceclofenac 6.0%, ketorolac 6.9%, naproxane 10.8%, ibuprofen 3.7%, indomethacin 3.5%, etoricoxib 6.2%, tramadol 15.4% and paracetamol 24.0% were used. Of the 324 patients, 33.6% received combination of analgesics: diclofenac+paracetamol 37.6%, aceclofenac+paracetamol 14.7%, ketorolac+ paracetamol 20.2%, tramadol+paracetamol 22.9% and diclofenac+tramadol 4.6%. Use of trade names was for 80.5% drugs and generic names for 19.5% drugs. NSAIDs were widely prescribed drugs. Use of selective was less comparing to non-selective NSAIDs. Tramadol was the most commonly prescribed opioid drug. Gastro protective agents were used with NSAIDs. Prescribers need to be encouraged to prescribe drugs only using generic names.Mediscope Vol. 4, No. 1: Jan 2017, Page 11-17

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Psychological Approaches in the Treatment of Chronic Pain Patients—When Pills, Scalpels, and Needles are Not Enough

Cited by 252 publications

References 72 publications

Characterization of Folded Recombinant Der p 5, a Potential Diagnostic Marker Allergen for House Dust Mite Allergy

Characterization of Folded Recombinant Der p 5, a Potential Diagnostic Marker Allergen for House Dust Mite Allergy

Current Psychosomatic Practice

Prescription of analgesics in orthopaedic outpatient department at a tertiary health care facility

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