Psychopharmacological effects of methanol stem bark extract of Crossopteryx febrifuga (Afzel ex G.Don) Benth

Salawu, Oluwakanyinsola; Tijani, A. Y.; Adamu, M.; Okhale, Samuel

doi:10.5455/bcp.20160223122941

Cited by 4 publications

(4 citation statements)

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“…Decreased physical activity exhibited by mercury-treated group could be the result of direct treatmentrelated toxicity This is in concordance with reports on drug-related toxicity; altered physical activity manifesting as sluggishness 33 . Body weight changes serve as a sensitive indication of the general health status of animal 33 , and are used as an indicator of health status of an organism and adverse effect of drugs and chemicals 34 . Changes in the body weight of Wistar rats treated with mercury were lower than that of the extracts treated groups.…”

Section: Discussionsupporting

confidence: 91%

Biochemical, Morphological and Molecular Assessments of Flavonoids of Phoenix dactylifera L. Following Exposure to Inorganic Mercury on the Liver of Wistar Rats.

Abubakar,

Agbon,

Musa

et al. 2024

Preprint

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Introduction: Mercury is a highly toxic metal that exerts adverse effects on humans and animals. Date palm (Phoenix dactylifera) is used in folk medicine to treat fever, and inflammation, among others. The present study aimed to evaluate the protective effects of aqueous and ethanol extracts of Phoenix dactylifera on mercury-induced kidney damage in Wistar rats.Design: 45 male rats (80–125g) were divided into nine groups (I-XI). Group 1 received 1mg/kg of distilled water, group II received mercury chloride (HgCl2) at 5 mg/kg; group III was pretreated with100 mg/kg of silymarin followed by 5 mg/kg of HgCl2; groups IV and V were pretreated with 500 mg/kg and 1000 mg/kg of aqueous extract of Phoenix dactylifera (AFPD) respectively, followed by 5 mg/kg of HgCl2; groups VI and VII were pretreated with 500 mg/kg and 1000 mg/kg of ethanol extract of Phoenix dactylifera L. (EFPD) respectively, followed by 5 mg/kg of HgCl2 while group VIII and IX received 1000 mg/kg of AFPD and EFPD respectively. After two weeks of oral administration, the animals were sacrificed and the blood and kidney tissue were collected for analyses.Results The present study showed that MDA significantly increased in HgCl2 group when compared to control while histological and histochemical changes in the kidney revealed severe degenerative changes. AFPD and EFPD extracts restored serum enzymes, electrolytes and antioxidant enzymes activity with significant increase in SOD activity in the AFPD (high dose) when compared to the HgCl2 treated group. This indicates some level of protection against HgCl2-induced changes in the kidneys of Wistar rats. The protective activity of the AFPD and EFPD may be attributed to the antioxidant properties of the phytochemicals, such as flavonoids, tannins etc.Conclusion The aqueous and ethanol extracts of Phoenix dactylifera are potential candidates for the management and treatment of ROS-induced kidney diseases.

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Section: Discussionsupporting

confidence: 91%

Biochemical, Morphological and Molecular Assessments of Flavonoids of Phoenix dactylifera L. Following Exposure to Inorganic Mercury on the Liver of Wistar Rats.

Abubakar,

Agbon,

Musa

et al. 2024

Preprint

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“…The chosen mushrooms was subjected to toxicological studies by giving methanol extract of the mushrooms to the rats for the safety confirmation of future clinical investigations. Earlier reports have shown that if the median lethal dose of a test substances is three times more than the minimum effective dose, the substance is recognized as positive aspirant for future studies [14]. The effect of Pleurotus eous methanol extract at different doses that is weight of the vital organs were monitored and documented which is represented in the Table 3.…”

Section: Resultsmentioning

confidence: 99%

Research on Acute Toxicity and the Effect of Methanol Extract Pleurotus Eous Mushroom in Rats: An In Vivo Study

Kumari¹

2023

J Gast Hepa Rep

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“…This study was carried out to provide information on the acute toxicity that may likely arise as a result of single dose exposure to aqueous suspension in order to determine the lethal dose (LD 50 ) of the crude powder of Phoenix dactylifera L. pollen via oro-gastric intubation. Lorke's (1983) method as modified by Salawu et al (2009) of acute toxicity study was adopted for this study. Experimental Protocol A total of eighteen (18) healthy, young female rats aged five to six weeks old as at the time of the experimental study and weighing between 80-100g were used for the study.…”

Section: Acute Toxicity Studymentioning

confidence: 99%

“…The rats were observed for clinical signs of toxicity and death during the first one hour, then monitored hourly for four hours and then periodically for every twenty four (24) hours. The rats were weighed daily for 7 days (Salawu et al, 2009). In the second phase of the acute toxicity study, the same procedure was repeated with different concentrations of the extract.…”

Section: Acute Toxicity Studymentioning

confidence: 99%

Phytochemical Analysis and Acute Toxicity Study on Aqueous Extract of Date Palm Pollen (DPP)

2023

AJBAR

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The present study was carried out to determine the phytochemical constituent and the acute toxicity of date palm pollen (DPP) using female albino rats. Phytochemical analysis of the aqueous extract of DPP was carried out to investigate the phytochemical content of DPP harvested in Northern Nigeria as there was paucity of this data. The acute toxicity study of the aqueous extract was also carried out to determine the dosage that was innocuous in Wistar rats. In the acute toxicity study carried out, eighteen rats were divided into two groups named I and II. In each of the groups, the rats were further subdivided into three groups and rats in this group were administered 10 mg/kg, 100 mg/kg and 1000 mg/kg of aqueous extract of DPP. The rats in group II were administered aqueous extract of DPP at concentrations of 1600 mg/kg, 2900 mg/kg and 5000mg/kg. There was no death or physical toxic characteristic displayed at the end of the study and histological examination of tissues displayed no damage to the histoachitecture of tissues examined showing thst the extract had no damaging effect on the tissues tested. Phytochemical analysis showed the presence of phytochemicals like alkaloids, flavonoids, cardenolites, tannins, saponins, terpenoids, steroids and carbohydrates which indicates the extract would play useful roles in ethnopharmacology.

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Psychopharmacological effects of methanol stem bark extract of Crossopteryx febrifuga (Afzel ex G.Don) Benth

Cited by 4 publications

References 0 publications

Biochemical, Morphological and Molecular Assessments of Flavonoids of Phoenix dactylifera L. Following Exposure to Inorganic Mercury on the Liver of Wistar Rats.

Biochemical, Morphological and Molecular Assessments of Flavonoids of Phoenix dactylifera L. Following Exposure to Inorganic Mercury on the Liver of Wistar Rats.

Research on Acute Toxicity and the Effect of Methanol Extract Pleurotus Eous Mushroom in Rats: An In Vivo Study

Phytochemical Analysis and Acute Toxicity Study on Aqueous Extract of Date Palm Pollen (DPP)

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