Psychophysiological Reactivity under Mental Stress in Atopic Dermatitis

Seiffert, Kristina; Hilbert, Edwin; Schaechinger, Hartmut; Zouboulis, Christos C.; Deter, Hans‐Christian

doi:10.1159/000084752

Cited by 50 publications

(43 citation statements)

References 48 publications

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“…They also report dysfunction of parasympathetic system in acute stress, inferred from HR changes in respiratory frequencies. Higher basal HR in atopic dermatitis was also observed by Seiffert et al [8]. However, though overall HR was higher in AD group, authors also reported lower HR…”

supporting

confidence: 68%

“…Most studies associate high anxiety with reduced HRV and increased HR, which can also be seen in anxiety disorders studies [23]. On the other hand, close similarities between allergy and anxiety were documented [8,19,20]. Similar findings in allergy and anxiety were also found in HPA axis reaction to stress, where both allergy and high trait anxiety subjects exhibited lowered cortisol responses [5,26].…”

Section: Subjective Stress Differencesmentioning

confidence: 78%

“…One of possible mechanisms of hypocortisolism is it being a result of chronic activation of HPA axis and, therefore, its inhibition through feedback regulation [7]. Similarly, autonomic nervous system dysregulation was described, however, while some studies showed sympathetic over-activation in allergy [5,8,9], other studies documented parasympathetic predominance [10][11][12][13].…”

mentioning

confidence: 99%

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Increased Heart Rate Variability in Allergic and Highly Trait Anxious Individuals

Rajčáni¹,

Soláriková²,

Brezina³

2017

JPP

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Autonomic dysregulations were repeatedly observed in people with allergic reactions. Contradictory results of sympathetic over-activation on one hand and parasympathetic predominance on the other, were described for both atopic dermatitis and allergic rhinitis. Secondly, psychological traits of high anxiety and depression described in allergic patients are mostly associated with increased sympathetic and decreased vagal modulation. To address inconsistency in prior findings, we aim to study autonomic nervous system changes in allergic and highly anxious people via HR (heart rate) and HRV (heart rate variability) measures during stressful and relax days in day to day life. We further assess differences between allergic diagnoses and impact of acute symptom occurrence on HR and HRV. 61 subjects (26 allergic, 18 healthy high trait anxious and 17 healthy low trait anxious) took part in this study. They were repeatedly measured for HR by a portable electrocardiographic device, and assessed their subjectively experienced stress during everyday life. HRV was analyzed using time-domain, spectral and non-linear analyses. We observed increased HRV and decreased HR in allergic patients and also in healthy highly anxious subjects, when compared to controls. Both atopic dermatitis and allergic rhinitis patients exhibited parasympathetic predominance or sympathetic withdrawal, seen in increased HRV and lowered HR. Described effects of parasympathetic predominance were, however, not present during acute symptoms occurrence.

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supporting

confidence: 68%

Section: Subjective Stress Differencesmentioning

confidence: 78%

mentioning

confidence: 99%

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Increased Heart Rate Variability in Allergic and Highly Trait Anxious Individuals

Rajčáni¹,

Soláriková²,

Brezina³

2017

JPP

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“…Psoriasis vulgaris (PSO) and atopic dermatitis (AD) are among the most important dermatological conditions in terms of prevalence, health-related quality of life (HRQL) impact, and societal economic burden [1,2,3,4,5,6,7,8,9,10]. While most cases of AD and PSO can be effectively controlled with emollients and topical treatments, some patients with extensive disease, outpatient treatment failure, acute deterioration, or highly impaired everyday functioning require inpatient care.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Inpatient Treatment on Quality of Life and Clinical Disease Severity in Atopic Dermatitis and Psoriasis Vulgaris – A Prospective Study

et al. 2006

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Background: Financial constraints challenge evidence of the effectiveness of dermatological inpatient management. Objective: To evaluate the effectiveness of hospitalization in atopic dermatitis and psoriasis regarding initial and sustained benefits. Methods: Prospective study on adults with psoriasis vulgaris (n = 22) and atopic dermatitis (n = 14). At admission, discharge, and 3 months after discharge, validated outcomes of objective and subjective disease severity were assessed by trained investigators. Results: Hospitalization resulted in substantial benefit in quality of life and clinical disease severity. Looking at mean scores, the observed benefit appeared stable until 3-month follow-up. The analysis of individual patient data revealed significant changes in disease severity between discharge and 3-month follow-up with some patients relapsing, others further improving. Reasons for hospitalization and treatment performed were not related to sustained benefit. Conclusions: In psoriasis vulgaris and atopic dermatitis, hospitalization effectively improved quality of life and clinical disease severity. Further research should focus on prognostic factors for sustained improvement.

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“…The study of Seiffert et al [21] shows an increased vegetative excitability level in patients with atopic dermatitis. A recent study compares 40 women who have diffuse unexplained hair loss with 40 controls.…”

Section: Discussionmentioning

confidence: 99%

Stressful Life Events and Pemphigus

Morell-Dubois¹,

Carpentier²,

Cottencin

et al. 2008

Dermatology

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Background: Stress might be a triggering factor causing pemphigus. We studied 11 consecutive cases of pemphigus over 5 years. Objective: Studying and looking for a link between severe life events and the history of the disease. Methods: An epidemiological retrospective and prospective study was carried out, including an interview and a collection of the clinical history; then the life events were integrated into the clinical history with the patient blind. Two scales were used: Paykel’s inventory (assessing the negative impact of life events) and the Mini International Neuropsychiatric Interview DSM-IV (MINI). Results: 10 patients out of 11 were included. With the MINI, 2 patients presented anxiety. Paykel’s inventory showed type 3 life events for numerous patients, life event type 4 for 7 patients and type 5 for 3 patients, happening from 1 to 6 months before the first signs or worsening of pemphigus. We found stressful life events before the start or worsening of pemphigus for all patients with no other risk factors. Conclusion: Stressful life events can worsen or trigger off a pemphigus. Psychological care, associated with the immunosuppressive treatment, should entail a better management of these patients.

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Psychophysiological Reactivity under Mental Stress in Atopic Dermatitis

Cited by 50 publications

References 48 publications

Increased Heart Rate Variability in Allergic and Highly Trait Anxious Individuals

Increased Heart Rate Variability in Allergic and Highly Trait Anxious Individuals

Effectiveness of Inpatient Treatment on Quality of Life and Clinical Disease Severity in Atopic Dermatitis and Psoriasis Vulgaris – A Prospective Study

Stressful Life Events and Pemphigus

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