Psychosocial indication for orthognathic surgery in patients with psychiatric comorbidities

Abstract

retinal ganglion cell layer in the inferior zone, which was significantly smaller in patients compared to healthy controls (P < 0.05 for both eyes). Possible mechanisms include blood vessel diameter changes caused by pericytes 8 or smoking; compared with the general population, patients with schizophrenia are more likely to smoke (Table 1). However, we have been able to rule out smoking as a factor by additional statistical analyses (Supplementary information: Tables S2 and S3). The changes in the blood vessel morphology may represent a genuine novel structural correlate of schizophrenia. Pending resolution of conflicting evidence 2,3 and inclusion of genetic factors 9 as well as confirmation by larger studies, the measurement of retinal blood vessel diameter could become a screening or diagnostic tool. 10