Pt(II) and Pd(II) Complexes with β‐Alanine

Abstract

A sequence of stages in the syntheses of isomeric bisamino acid complexes of Pt(II) with β-aminopropionic acid (β-alanine = β-AlaH) has been studied by the 195Pt NMR spectroscopy. The techniques have been developed of the synthesis of the cis- and trans-bischelates of Pt(II) and Pd(II) with β-alanine as well as of the halide complexes of trans-[M(β-AlaH)2Cl2] (M = Pt, Pd) and trans-K2[Pt(β-Ala)2I2] types. The NMR spectroscopy and IR spectroscopy (in the nuclei of 195Pt,13C,1H) and X-ray diffraction analysis have been used to examine the structures of the synthesized compounds.

Self-Assembly Motifs of Water in Crystals of Palladium β-Amino Acid Complexes Influenced by Methyl Substitution on the Amino Acid Backbone

“…The 1 H and 13 C nuclear magnetic resonance (NMR) spectra also show signals indicative of only one isomer in solution. This complex was the subject of a previous paper by Krylova et al [19] and a room temperature crystal structure of trans-bis(3-aminopropanoato)palladium was reported. Krylova and co-workers also reported that the cis-isomer could be synthesized by heating the trans isomer to 80°followed by cooling to 0°but no X-ray crystal structure was obtained and we could not reproduce that finding.…”

“…This is somewhat surprising since a beta-amino acid should form a stable 6-membered ring chelate with metals, coordinating through the carboxylate O atom and the amino N atom. There are a number of β-amino acid complexes of first-row transition metals such as Co and Cu [9][10][11][12][13][14][15][16] but many fewer examples of heavier metals such as Pd and Pt [17][18][19]. It is not surprising that the hydrogen-bonding (H-bonding) capabilities of amino acids play a large role in the solid-state structures of the their metal complexes.…”

Antiproliferative Activity of PtIIComplexes with Carboxylated Phosphanes in Chelated or Ring‐Opened Forms

“…Ligand L4 was prepared by coupling L3 with N-hydroxysuccinimide (NHS) by use of dicyclohexylcarbodiimide (DCC) and triethylamine (TEA). [27] Elemental analyses were carried out with a EA3000 CHN Elemental Analyzer (EuroVector, Milano, Italy). Complexes O6 and C5 were synthesized according to Dhara's method, [28] with some modification in the case of C5.…”

“…the reaction of K 2 [PtI 4 ] with β-alanine L5 in the presence of KOH) [27] was employed to obtain the C compound C5. A published modification of Dhara's method (i.e.…”

Amino acid inspired microscale organization of metallic nanocrystals

“…Published reports suggest that Pt (II) and (IV) are capable of forming coordination complexes with α-amino acids, including alanine. [34][35][36] The Pt (II) coordinated complexes showed a prominent peak shift for both N-H and C=O stretching vibrations. Hence it is proposed that the peak shift associated with the Pt-alanine superstructures is due to the formation of a bonding interaction between platinum and alanine.…”