2021
DOI: 10.1101/2021.07.24.453632
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PTEN mutant NSCLC require ATM to suppress pro-apoptotic signalling and evade radiotherapy

Abstract: Background: Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN. These tumors are supposed to be more resistant to radiation, chemo- and immunotherapy. Methods: Using CRISPR genome editing, we deleted PTEN in a human tracheal stem cell-like cell line as well generated primary murine NSCLC, proficient or deficient for Pten, in vivo. These models were used to verif… Show more

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