Pterodontic Acid Isolated from Laggera pterodontaInhibits Dengue Virus Serotype 2 Infection

Abstract

Dengue is the most important arbovirus disease in the world in terms of the highest morbidity and mortality. Unfortunately, there is no specific medication for it so far. In the present study, we investigated the anti-DENV-2 activity of Pterodontic acid, isolated from Laggera pterodonta. Pterodontic acid was found to have strong activity in vitro against DENV-2 with low cytotoxicity. These findings suggest that Pterodontic acid has the potential to be developed into an anti virus drug for the prevention and treatment of DENV-2 virus infection.