Pterostilbene increases Fas expression in T-lymphoblastic leukemia cell lines

Ramezani, Gelareh; Pourgheysari, Batoul; Shirzad, Hedayatollah; Sourani, Zahra

doi:10.4103/1735-5362.251853

Cited by 12 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fas, as a member of the death-inducing family of tumor necrosis factors (receptors with an intracellular death domain) can initiate the extrinsic apoptosis signaling pathway. [ 20 ] In the present case, Fas expression was not detected in the CD4 + ATLL, this might be associated with a reduction in the apoptosis rate and may be one of the reasons for the long-term survival of ATLL cells.…”

Section: Discussionmentioning

confidence: 53%

Cutaneous plaque in adult T cell leukemia/lymphoma

Lei

Qian

et al. 2020

Medicine

View full text Add to dashboard Cite

Rationale: The rarity of adult T cell leukemia/lymphoma (ATLL) in China, coupled with its clinicopathologic mimicry of primary skin disease, poses a diagnostic challenge. The method of diagnosis and mechanism of immune regulation in ATLL are discussed in the present report. Patient concerns: A 51-year-old Chinese man was admitted to the hospital with 2-years history of systemic plaque lesions and 1-year history of left ankle joint pain. Diagnoses: The patient was diagnosed with ATLL based on the results of flow cytometry immunophenotype and human T-cell lymphotropic virus type 1 (HTLV-1) serology. Interventions: The patient received 3 cycles of cyclophosphamide, epirubicin/ vinorelbine, and dexamethasone (CHOP) chemotherapy. However, he relapsed and did not respond to epirubicin, vindesine, etoposide, dexamethasone (EPOCH) chemotherapy. Outcomes: His family discontinued the treatment and opted for hospice care. Lessons: Patch and plaque ATLL types exhibits a better survival rate, but atypical skin patches delays the diagnosis of ATLL and negatively affects the patient survival. Based on the present findings, we suggest that patients with petal-like nuclear lymphocytes in blood smears, a high CD4: CD8 ratio, and strong CD25 expression should undergo HTLV-1 serology testing.

show abstract

Section: Discussionmentioning

confidence: 53%

Cutaneous plaque in adult T cell leukemia/lymphoma

Lei

Qian

et al. 2020

Medicine

View full text Add to dashboard Cite

show abstract

“…It was initially isolated from sandalwood, but is also present in fruits, including grapes and blueberries [ 130 ]. The pterostilbene wide range of bioactive properties comprehends antioxidant, anti-inflammatory, anticancer, and cardioprotective effects [ 131 , 132 , 133 , 134 ], which altogether may contribute to the prevention of various chronic human diseases. Moreover, it seems to improve cognitive performances [ 135 ].…”

Section: Polyphenols’ Effects In Dedmentioning

confidence: 99%

Evidence of Polyphenols Efficacy against Dry Eye Disease

et al. 2021

View full text Add to dashboard Cite

Dry eye disease is a multifactorial pathology compromising the quality of life of patients, resulting in significant damage of the ocular surface and discomfort. The current therapeutical strategies are not able to definitively resolve the underlying causes and stop the symptoms. Polyphenols are promising natural molecules that are receiving increasing attention for their activity/effects in counteracting the main pathologic mechanisms of dry eye disease and reducing its symptoms. In the present review, a deep literature search focusing on the main polyphenols tested against dry eye disease was conducted, analyzing related in vitro, in vivo, and clinical studies to provide a comprehensive and current review on the state of the art. Polyphenols present multiple effects against dry eye diseases-related ocular surface injury. In particular, the observed beneficial effects of polyphenols on corneal cells are the reduction of the pathological processes of inflammation, oxidative stress, and apoptosis and modulation of the tear film. Due to numerous studies reporting that polyphenols are effective and safe for treating the pathological mechanisms of this ocular surface disease, we believe that future studies should confirm and extend the evidence of polyphenols efficacy in clinical practice against dry eye disease and help to develop new ophthalmic drug(s).

show abstract

“…Fas or CD95/APO-1, a member of the superfamily of tumor necrosis factor receptors, is one of the significant molecules contributing to the extrinsic pathway of apoptosis (50). Binding apoptotic ligands to Fas receptor leads to homo-trimerization of this receptor, signaling transduction, death complex formation, and cell death (89). It is suggested that A to G substitution at the mentioned position leads to Fas dysregulation and resistance to treatment.…”

Section: Polymorphismsmentioning

confidence: 99%

Drug Resistance Biomarkers and Their Clinical Applications in Childhood Acute Lymphoblastic Leukemia

et al. 2020

View full text Add to dashboard Cite

Biomarkers are biological molecules found in body fluids or tissues, which can be considered as indications of a normal or abnormal process, or of a condition or disease. There are various types of biomarkers based on their application and molecular alterations. Treatment-sensitivity or drug resistance biomarkers include prognostic and predictive molecules with utmost importance in selecting appropriate treatment protocols and improving survival rates. Acute lymphoblastic leukemia (ALL) is the most prevalent hematological malignancy diagnosed in children with nearly 80% cure rate. Despite the favorable survival rates of childhood ALL (chALL), resistance to chemotherapeutic agents and, as a consequence, a dismal prognosis develops in a significant number of patients. Therefore, there are urgent needs to have robust, sensitive, and disease-specific molecular prognostic and predictive biomarkers, which could allow better risk classification and then better clinical results. In this article, we review the currently known drug resistance biomarkers, including somatic or germ line nucleic acids, epigenetic alterations, protein expressions and metabolic variations. Moreover, biomarkers with potential clinical applications are discussed.

show abstract

Pterostilbene increases Fas expression in T-lymphoblastic leukemia cell lines

Cited by 12 publications

References 30 publications

Cutaneous plaque in adult T cell leukemia/lymphoma

Cutaneous plaque in adult T cell leukemia/lymphoma

Evidence of Polyphenols Efficacy against Dry Eye Disease

Drug Resistance Biomarkers and Their Clinical Applications in Childhood Acute Lymphoblastic Leukemia

Contact Info

Product

Resources

About